| Full text | |
| Author(s): |
Ochoa-Amaya, Julieta E.
[1]
;
Malucelli, Benjamin E.
[2]
;
Cruz-Casallas, Pablo E.
[3]
;
Nasello, Antonia G.
[4]
;
Felicio, Luciano F.
[2]
;
Carvalho-Freitas, Maria I. R.
[2]
Total Authors: 6
|
| Affiliation: | [1] Univ Llanos, Fac Ciencias Agropecuarias & Recursos Nat, Escuela Med Vet & Zootecnia, Villavicencio - Colombia
[2] Univ Sao Paulo, Fac Med Vet & Zootecnia, Dept Patol, BR-05508900 Sao Paulo - Brazil
[3] Univ Llanos, Inst Acuicultura, Villavicencio - Colombia
[4] Fac Ciencias Med Santa Casa Sao Paulo, Dept Ciencias Fisiol, Sao Paulo - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | NEUROIMMUNOMODULATION; v. 18, n. 4, p. 245-253, 2011. |
| Web of Science Citations: | 9 |
| Abstract | |
Objectives: The effects of short-term 5-day and long-term 30-day hyperprolactinemia induced by domperidone (1.7 mg/kg/day, s.c.) or ectopic pituitary graft on the acute inflammatory response induced by carrageenan were evaluated in male rats. Both models of hyperprolactinemia effectively increased serum prolactin (PRL) levels. Methods: The volume in milliliters of inflammatory edema was measured by plethysnnography 1, 2, 3, 4, 6, 8 and 24 h after carrageenan injection. The areas under the inflammatory time-response curves were compared. Additionally, the effects of hyperprolactinemia on body weight and serum corticosterone levels were evaluated. Results: In both domperidone-treated and pituitary graft-implanted animals, short-term 5-day hyperprolactinemia increased the inflammatory response, while long-term 30-day hyperprolactinemia had anti-inflammatory effects. Body weight was not affected by either short- or long-term hyperprolactinennia. Conclusion: These results show that PRL has biphasic effects on the carrageenan-induced inflammatory response. Copyright (C) 2011 S. Karger AG, Basel (AU) | |