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Low Power Laser Therapy on Acute Inflammatory Processes- A Dosimetry Study

Grant number: 08/00723-4
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): June 01, 2008
Effective date (End): October 31, 2010
Field of knowledge:Engineering - Biomedical Engineering - Bioengineering
Principal Investigator:Martha Simões Ribeiro
Grantee:Daiane Thais Meneguzzo
Home Institution: Instituto de Pesquisas Energéticas e Nucleares (IPEN). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São Paulo , SP, Brazil


The phototherapy with low intensity laser can bring a lot of therapeutic benefits whatever a few is known about the protocols of this therapy. So, the purpose of the present study is to investigate the effects of the phototherapy on acute inflammatory process testing different protocols of irradiation. The rat paw oedema will be induced by sub-plantar injection of carrageenan and the paw volume will be measured before, and 1, 2, 3 and 4 hours after the injection using a plethysmometer. To investigate the protocols, six-hundred male mice (brown and white) will be divided into 6 groups (n=6). After 1 and 2 h of carrageenan injection, animals will be irradiated using a low-power infrared laser (l= 810nm) accordingly to energy and power applied: 1/30 (1 Joule e 30mW); 1/60 (1J e 60mW); 1/100 (1J e 100mW); 3/30 (3J e 30mW); 3/60 (3J e 60mw); 3/100 (3J e 100mW). Two more groups will be done by animals not irradiated: negative control (just rat paw oedema) and positive control (oedema plus administration of an anti-inflammatory drug- sodium diclofenac 1ml/Kg). The analyses will be made by RT-PCR technique to COX-2 e COX-1 and also will be measured oedema, PGE2, Nitrotirosin and Mieloperoxidase (MPO). The data obtained will be analyzed and the best statistic test will be done.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MENEGUZZO, DAIANE THAIS; LOPES, LUCIANA ALMEIDA; PALLOTA, RODNEY; SOARES-FERREIRA, LEILA; BRANDAO LOPES-MARTINS, RODRIGO ALVARO; RIBEIRO, MARTHA SIMOES. Prevention and treatment of mice paw edema by near-infrared low-level laser therapy on lymph nodes. Lasers in Medical Science, v. 28, n. 3, p. 973-980, MAY 2013. Web of Science Citations: 16.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MENEGUZZO, Daiane Thais. Phototherapy with low intensity laser in carrageenan-induced acute inflammatory process in mice paw - dosimetry studies. 2010. Doctoral Thesis - Instituto de Pesquisas Energéticas e Nucleares - IPEN-CNEN/SP São Paulo.

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