Oral Mucosal Melanoma of the Mandibular Gingiva: A Case Report

Autor(es)

Lourenco, Silvia Vanessa ^[1] ; Bologna, Sheyla Batista ^[1] ; Colucci, Fabiana ; Neto, Cyro Festa ^[2] ; Montenegro, Fabio L. M. ^[3] ; Nico, Marcello Menta S. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med, Sch Dent, Dept Gen Pathol, BR-05508000 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Med, Dept Dermatol, BR-05508000 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Med, Hosp Clin, Dept Head & Neck Surg, BR-05508000 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CUTIS; v. 86, n. 2, p. 89-93, AUG 2010.
• Citações Web of Science: 5

Resumo

Orla mucosal melanoma is rare and is reported to be more aggressive than cutaneous melanoma. The incidence of oral mucosal melanoma peaks at 41 to 60 years of age and the male to female ratio is 2 to 1. Preferred sites in the oral mucosa include the hard palate and maxillary alveolar crests. Risk factors have not been clearly identified, but melanotic pigmentation is present in one-third of patients prior to the diagnosis of melanoma. We report an unusual case of oral mucosal melanoma of the mandibular gingiva with the main characteristics of an in situ lesion and areas of superficial invasion in a 45-year-old woman. The patient was treated with surgical resection of the lesion and a 54-month follow-up shows no evidence of recurrence. Oral mucosal melanomas are aggressive neoplasms that may arise from prior pigmented lesions in the oral mucosa. Classification of these tumors is not well-established and the main prognostic factor appears to be lymph node compromise. The main treatment modality is surgical resection. Cutis. 2010;86:89-93. (AU)

• Processo FAPESP: 06/56625-5 - Melanomas orais: estudo morfologico e analise imuno-histoquimica de marcadores tumorais e moleculas de adesao por meio de "tissue microarray".
• Beneficiário: Silvia Vanessa Lourenço
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 07/50319-2 - Melanomas orais: estudo morfológico e análise imuno-histoquímica das claudinas e sua relação com marcadores tumorais: análise por meio de tissue microarray
• Beneficiário: Sheyla Batista Bologna Lopes
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica