Prenatal lipopolysaccharide reduces motor activity after an immune challenge in adult male offspring

Autor(es)

Kirsten, Thiago Berti ^[1] ; Taricano, Marina ^[1] ; Florio, Jorge Camilo ^[1] ; Palermo-Neto, Joao ^[1] ; Bernardi, Maria Martha ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Neuroimmunomodulat Res Grp, Dept Pathol, Sch Vet Med, BR-05508000 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Behavioural Brain Research; v. 211, n. 1, p. 77-82, JUL 29 2010.
• Citações Web of Science: 44

Resumo

Prenatal lipopolysaccharide (LPS) exposure causes reproductive, behavioral and neurochemical injuries in both the mother and pups. Previous investigations by our group showed that prenatal LPS administration (100 mu g/kg, i.p.) on gestational day 9.5 impaired the male offspring's social behavior in infancy and adulthood. In the present study, we investigated whether these social behavioral changes were associated with motor activity impairment. Male rat pups treated prenatally with LPS or not were tested for reflexological development and open field general activity during infancy. In adulthood, animals were tested for open field general activity, haloperidol-induced catalepsy and apomorphine-induced stereotypy; striatal dopamine levels and turnover were also measured. Moreover, LPS-treated or untreated control pups were challenged with LPS in adulthood and observed for general activity in the open field. In relation to the control group, the motor behavior of prenatally treated male pups was unaffected at basal levels, both in infancy and in adulthood, but decreased general activity was observed in adulthood after an immune challenge. Also, striatal dopamine and metabolite levels were decreased in adulthood. In conclusion, prenatal LPS exposure disrupted the dopaminergic system involved with motor function, but this neurochemical effect was not accompanied by behavioral impairment, probably due to adaptive plasticity processes. Notwithstanding, behavioral impairment was revealed when animals were challenged with LPS, resulting in enhanced sickness behavior. (C) 2010 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 06/54587-9 - Efeitos da administração pré-natal de LPS nos sistemas dopaminérgico e serotoninérgico centrais da prole masculina de ratos
• Beneficiário: Thiago Berti Kirsten
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 04/14128-0 - Neuroimunomodulação: efeitos do estresse e de citocinas nas relações bidirecionais entre os sistemas nervosos central e imune
• Beneficiário: João Palermo Neto
• Modalidade de apoio: Auxílio à Pesquisa - Temático