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The functional Toll-like receptor 4 Asp299Gly polymorphism is associated with lower left ventricular mass in hypertensive women

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Sales, Maria L. [1] ; Schreiber, Roberto [1] ; Ferreira-Sae, Maria C. S. [1] ; Fernandes, Maruska N. [1] ; Piveta, Cristiane [1] ; Cipolli, Jose A. A. [1] ; Calixto, Antonio [1] ; Matos-Souza, Jose R. [1] ; Geloneze, Bruno [1] ; Franchini, Kleber G. [1] ; Nadruz, Jr., Wilson [1]
Número total de Autores: 11
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Sch Med, Dept Internal Med, Campinas, SP - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: Clinica Chimica Acta; v. 411, n. 9-10, p. 744-748, MAY 2 2010.
Citações Web of Science: 8

Background: This study investigated the impact of a putative functional TLR4 polymorphism (Asp299Gly) on left ventricular (LV) structure in hypertensive subjects. Methods: A sample of 443 patients (266 women and 177 men) was evaluated by clinical history, physical examination, anthropometry, analysis of inflammatory and metabolic parameters, echocardiography and TLR4 Asp299Gly genotyping. In addition, the relationship between the polymorphism and in vitro lipopolysaccharide responsiveness of peripheral blood monocytic cells was also assessed. Results: Women carrying the 299Gly allele presented lower posterior wall thickness (p = 0.01), interventricular septum thickness (p = 0.04). LV mass (p = 0.01) and LV mass index (p = 0.03), as well as a reduced prevalence of LV hypertrophy (p = 0.002), in comparison to women with the wild-type genotype. These results were confirmed by stepwise and logistic regression analyses adjusted for potential confounders. Conversely, the 299Gly allele did not influence LV structure in men. Furthermore, in vitro assays revealed that monocytes of either men or women heterozygous for the 299Gly allele presented a lower lipopolysaccharide-induced production of interleukin-6, compared to non-carriers. Conclusions: The functional TLR4 Asp299Gly polymorphism is associated with lower LV mass in hypertensive women. These findings suggest that interactions among gender, LV remodeling and TLR4 gene variants may occur in hypertensive subjects. (C) 2010 Elsevier B.V. All rights reserved. (AU)

Processo FAPESP: 05/56986-5 - Mecanotransdução vascular: implicações na aterogênese
Beneficiário:Wilson Nadruz Junior
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores