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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

GABA and nitric oxide in the PVN are involved in arterial pressure control but not in the chemoreflex responses in rats

Texto completo
Autor(es):
Cruz, Josiane C. [1] ; Machado, Benedito H. [1]
Número total de Autores: 2
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Physiol, BR-14049900 Ribeirao Preto, SP - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL; v. 146, n. 1-2, p. 47-55, MAR 12 2009.
Citações Web of Science: 9
Resumo

GABAergic, nitrergic and glutamatergic mechanisms in the PVN on the baseline mean arterial pressure (MAP), heart rate (HR) and on the cardiovascular responses to chemoreflex activation in awake rat were evaluated. Chemoreflex was activated with KCN before and after microinjections into the PVN. Bicuculline into the PVN increased baseline MAP (94+/-3 vs 113+/-5 mmHg) and HR (350+/-9 vs 439+/-18 bpm) but had no effect on the pressor (49+/-5 vs 47+/-6 mmHg) or bradicardic (-213+/-23 vs -256+/-42 bpm) responses (n=7). Kynurenic acid into the PVN (n=6) produced no significant changes in the MAP (98+/-3 vs 100+/-3 mmHg), HR (330+/-5 vs 339+/-12 mmHg) or in the pressor (50+/-4 vs 42+/-4 mmHg) and bradicardic (-252+/-4 vs -285+/-16 bpm) responses to chemoreflex. L-NAME into the PVN (n=8) produced increase in the MAP (94+/-3 vs 113+/-5 mmHg) and HR (350+/-9 vs 439+/-18 bpm) but had no effect on the pressor (52+/-5 vs 47+/-6 mmHg) or bradicardic (-253+/-19 vs -320+/-25 bpm) responses to chemoreflex. We conclude that GABA(A) and nitric oxide in the PVN are involved in the maintenance of the baseline MAP but not in the modulation of the responses to chemoreflex. The results also show that Glutamate receptors in the PVN are not involved in maintenance of the baseline MAP, HR or in the cardiovascular responses to chemoreflex in awake rats. (C) 2008 Elsevier B.V. All rights reserved. (AU)

Processo FAPESP: 05/50382-0 - Avaliação da participação de mecanismos GABAérgicos e glutamatérgicos na modulação de componente simpato-excitatório do quimiorreflexo no núcleo paraventricular do hipotálamo de ratos não anestesiados
Beneficiário:Josiane de Campos Cruz
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 04/03285-7 - Mecanismos centrais da excitação simpática promovida pela hipóxia
Beneficiário:Benedito Honorio Machado
Linha de fomento: Auxílio à Pesquisa - Temático