Mitochondrial Network Size Scaling in Budding Yeast

Autor(es)

Rafelski, Susanne M. ^{[1, 2]} ; Viana, Matheus P. ^[3] ; Zhang, Yi ^{[1, 4, 5]} ; Chan, Yee-Hung M. ^{[1, 2]} ; Thorn, Kurt S. ^[1] ; Yam, Phoebe ^[6] ; Fung, Jennifer C. ^[6] ; Li, Hao ^{[1, 2]} ; Costa, Luciano da F. ^[3] ; Marshall, Wallace F. ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 - USA

^[2] Univ Calif San Francisco, Ctr Syst & Synthet Biol, San Francisco, CA 94143 - USA

^[3] Univ Sao Paulo, Inst Fis Sao Carlos, Sao Carlos, SP - Brazil

^[4] Peking Univ, Ctr Theoret Biol, Beijing 100871 - Peoples R China

^[5] Peking Univ, Sch Phys, Beijing 100871 - Peoples R China

^[6] Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA - USA

• Tipo de documento: Artigo Científico
• Fonte: Science; v. 338, n. 6108, p. 822-824, NOV 9 2012.
• Citações Web of Science: 72

Resumo

Mitochondria must grow with the growing cell to ensure proper cellular physiology and inheritance upon division. We measured the physical size of mitochondrial networks in budding yeast and found that mitochondrial network size increased with increasing cell size and that this scaling relation occurred primarily in the bud. The mitochondria-to-cell size ratio continually decreased in aging mothers over successive generations. However, regardless of the mother's age or mitochondrial content, all buds attained the same average ratio. Thus, yeast populations achieve a stable scaling relation between mitochondrial content and cell size despite asymmetry in inheritance. (AU)

• Processo FAPESP: 05/00587-5 - Modelagem por redes (grafos) e técnicas de reconhecimento de padrões: estrutura, dinâmica e aplicações
• Beneficiário: Roberto Marcondes Cesar Junior
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 07/50882-9 - Caracterização e modelagem de redes biológicas
• Beneficiário: Matheus Palhares Viana
• Modalidade de apoio: Bolsas no Brasil - Doutorado