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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Experimental model of facial paralysis by nerve compression in primates (Callithrix sp.): A new model of facial paralysis in small nonhuman primates

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Autor(es):
Neiva, Felipe Costa [1] ; Borin, Andrei [1] ; Cinini, Simone [2] ; Mello, Luiz Eugenio A. M. [2] ; Cruz, Oswaldo Laercio M. [1] ; Testa, Jose Ricardo G. [1]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Fed Univ Sao Paulo UNIFESP, Otorhinolaryngol & Head & Neck Surg Dept, Sao Paulo - Brazil
[2] Fed Univ Sao Paulo UNIFESP, Dept Physiol, Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: ACTA OTO-LARYNGOLOGICA; v. 132, n. 11, p. 1239-1242, NOV 2012.
Citações Web of Science: 2
Resumo

Conclusion: We conclude that facial nerve injury induced by compression is associated with a reasonable time window (4 weeks) that allows possible neurotrophic effects to be analyzed. Additionally, there are no hints of cross-innervation by the contralateral facial nerve or parallel innervation by other nerves in the hemiface ipsilateral to the injured nerve. Objective: The aim of this work was to develop an experimental model of facial nerve injury in nonhuman primates (Callithrix sp.). Methods: In this study, individuals of the non-human primate species Callithrix sp. were subjected to three different types of facial nerve injury, and they were observed for 27 days after surgery by video to record their facial movements. Results: Two types of nerve compression caused severe initial facial paralysis followed by gradual recovery until normal levels were reached at the end of the evaluation period. Injury induced by nerve resection was followed by a complete lack of facial movement recovery. (AU)

Processo FAPESP: 09/52805-7 - Efeito do GCSF sobre a regeneração do nervo facial de primatas
Beneficiário:Oswaldo Laércio Mendonça Cruz
Modalidade de apoio: Auxílio à Pesquisa - Regular