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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Experimental model of facial paralysis by nerve compression in primates (Callithrix sp.): A new model of facial paralysis in small nonhuman primates

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Author(s):
Neiva, Felipe Costa [1] ; Borin, Andrei [1] ; Cinini, Simone [2] ; Mello, Luiz Eugenio A. M. [2] ; Cruz, Oswaldo Laercio M. [1] ; Testa, Jose Ricardo G. [1]
Total Authors: 6
Affiliation:
[1] Fed Univ Sao Paulo UNIFESP, Otorhinolaryngol & Head & Neck Surg Dept, Sao Paulo - Brazil
[2] Fed Univ Sao Paulo UNIFESP, Dept Physiol, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: ACTA OTO-LARYNGOLOGICA; v. 132, n. 11, p. 1239-1242, NOV 2012.
Web of Science Citations: 2
Abstract

Conclusion: We conclude that facial nerve injury induced by compression is associated with a reasonable time window (4 weeks) that allows possible neurotrophic effects to be analyzed. Additionally, there are no hints of cross-innervation by the contralateral facial nerve or parallel innervation by other nerves in the hemiface ipsilateral to the injured nerve. Objective: The aim of this work was to develop an experimental model of facial nerve injury in nonhuman primates (Callithrix sp.). Methods: In this study, individuals of the non-human primate species Callithrix sp. were subjected to three different types of facial nerve injury, and they were observed for 27 days after surgery by video to record their facial movements. Results: Two types of nerve compression caused severe initial facial paralysis followed by gradual recovery until normal levels were reached at the end of the evaluation period. Injury induced by nerve resection was followed by a complete lack of facial movement recovery. (AU)

FAPESP's process: 09/52805-7 - Effect of GCSF on facial nerve regeneration of primates
Grantee:Oswaldo Laércio Mendonça Cruz
Support type: Regular Research Grants