Inflammation in cancer cachexia: To resolve or not to resolve (is that the question?)

Autor(es)

Seelaender, Marilia ^[1] ; Batista Junior, Miguel ^{[1, 2]} ; Lira, Fabio ^{[1, 3]} ; Silverio, Renata ^[1] ; Rossi-Fanelli, Filippo ^[4]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Biomed Sci, Canc Metab Res Grp, BR-05508900 Sao Paulo - Brazil

^[2] Univ Mogi das Cruzes, Ctr Integrated Biotechnol, Lab Adipose Tissue Biol, Mogi Das Cruzes - Brazil

^[3] Univ Fed Sao Paulo UNIFESP, Dept Physiol, Div Nutr Physiol, Sao Paulo - Brazil

^[4] Univ Roma La Sapienza, Dept Clin Med, Rome - Italy

• Tipo de documento: Artigo Científico
• Fonte: Clinical Nutrition; v. 31, n. 4, p. 562-566, AUG 2012.
• Citações Web of Science: 26

Resumo

Background \& aims: Cachexia is associated with poor prognosis and shortened survival in cancer patients. Growing evidence points out to the importance of chronic systemic inflammation in the aetiology of this syndrome. In the recent past, chronic inflammation was considered to result from overexpression and release of pro-inflammatory factors. However, this conception is now the focus of debate, since the importance of a crescent number of pro-resolving agents in the dissolution of inflammation is now recognised - leading to the hypothesis that chronic inflammation occurs rather due to failure in the resolution process. We intend to put forward the possibility that this may also be occurring in cancer cachexia. Methods: Recent reviews on inflammation and cachexia, and on the factors involved in the resolution of inflammation are discussed. Results: The available information suggests that indeed, inflammation resolution failure may be present in cachexia and therefore we speculate on possible mechanisms. Conclusions: We emphasise the importance of studying resolution-related mechanisms in cancer cachexia and propose the opening of a new venue for cachexia treatment. (C) 2012 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. (AU)

• Processo FAPESP: 08/54091-9 - Regulação e síntese de adipocinas na caquexia associada ao câncer: possível interação entre PPAR-gama e NF kappaB
• Beneficiário: Marilia Cerqueira Leite Seelaender
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 09/53510-0 - Suplementacao com acai: estudo do efeito anti-inflamatorio na caqueixa associada ao cancer.
• Beneficiário: Marilia Cerqueira Leite Seelaender
• Linha de fomento: Auxílio à Pesquisa - Regular