A silver complex with tryptophan: Synthesis, structural characterization, DFT studies and antibacterial and antitumor assays in vitro

Autor(es)

Carvalho, Marcos A. ^[1] ; de Paiva, Raphael E. F. ^[1] ; Bergamini, Fernando R. G. ^[1] ; Gomes, Alexandre F. ^[1] ; Gozzo, Fabio C. ^[1] ; Lustri, Wilton R. ^[2] ; Formiga, Andre L. B. ^[1] ; Shishido, Silvia M. ^[3] ; Ferreira, Carmen V. ^[3] ; Corbi, Pedro P. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Inst Chem, BR-13083970 Campinas, SP - Brazil

^[2] Centro Univ Araraquara, Biol & Hlth Sci Dept, BR-14801320 Araraquara, SP - Brazil

^[3] Univ Estadual Campinas, Lab Bioassays & Signal Transduct, Dept Biochem, Inst Biol, BR-13083970 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Molecular Structure; v. 1031, p. 125-131, JAN 16 2013.
• Citações Web of Science: 24

Resumo

The synthesis, spectroscopic characterization and biological assays of a new silver(I) complex with L-tryptophan (TRP) are presented. Elemental and thermal analyses and ESI-QTOF mass spectrometric measurements of the solid compound suggest the composition AgC11H11N2O2. Infrared and solid-state NMR analyses indicate coordination of TRP to Ag(I) ion through the nitrogen of the NH2 group and also through the oxygen of carboxylate group. Theoretical (DFT) calculations permit proposing an optimized geometry for the complex. Antibacterial assays indicated that the Ag-TRP complex is effective against Staphylococcus aureus and Enterococcus faecalis (Gram-positive), and Pseudomonas aeruginosa and Escherichia coli (Gram-negative) bacterial strains. The complex was also cytotoxic against Panc-1 (human pancreatic carcinoma) and SK-Mel 103 (human melanoma) cells. (C) 2012 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 06/55367-2 - Complexos metálicos de platina (II), platina (IV), paládio (II), ouro (I) e ouro (III) com aminoácidos e derivados: síntese, caracterização e aplicações farmacológicas
• Beneficiário: Pedro Paulo Corbi
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 08/57805-2 - Instituto de Bioanalítica
• Beneficiário: Lauro Tatsuo Kubota
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 12/08230-2 - Síntese, caracterização e estudo das atividades farmacológicas de complexos metálicos de Ag(I), Au(I), Pt(II) e Pd(II) com ligantes bioativos
• Beneficiário: Pedro Paulo Corbi
• Modalidade de apoio: Auxílio à Pesquisa - Regular