Eosinophils may predict occult lymph node metastasis in early oral cancer

Autor(es)

Oliveira, D. T. ^[1] ; Biassi, T. P. ^[1] ; Faustino, S. E. S. ^[1] ; Carvalho, A. L. ^[2] ; Landman, G. ^[3] ; Kowalski, L. P. ^[4]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Stomatol, Area Pathol, Bauru Sch Dent, BR-17012901 Sao Paulo - Brazil

^[2] Canc Hosp Barretos, Dept Head & Neck Surg, Fundacao Pio 12, Sao Paulo - Brazil

^[3] AC Camargo Canc Hosp, Dept Pathol, Sao Paulo - Brazil

^[4] AC Camargo Canc Hosp, Dept Head & Neck Surg & Otorhinolaryngol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CLINICAL ORAL INVESTIGATIONS; v. 16, n. 6, p. 1523-1528, DEC 2012.
• Citações Web of Science: 10

Resumo

Objective The aim of this study was to investigate whether tumor-associated tissue eosinophilia (TATE) in early oral squamous cell carcinoma (OSCC) would aid in predicting occult lymph node metastasis. Patients and methods Seventy-one patients undergoing elective neck dissection for T1 and T2 OSCC were evaluated for clinical features, prognosis, and TATE. The degree of TATE in OSCC was statistically analyzed in relation to the clinicopathological features, tumor invasion, occult lymph node metastasis, and survival using chi (2) test and Kaplan-Meier method. Results Statistical analysis revealed that intense TATE was a significant feature (p = 0.004) to predict occult lymph node metastasis in patients with early OSCC. All regional recurrences of the OSCC occurred in patients showing intense TATE. Conclusions These results suggest that intense TATE can be clinically used as a predictive factor for occult lymph node metastasis. Clinical relevance The presence of intense TATE is an adjunctive histopathological marker to reinforce the indication of elective neck dissection of the patients with early OSCC. (AU)

• Processo FAPESP: 09/10770-2 - Eosinofilos podem ser considerados marcadores morfológicos da invasão local progressiva do câncer de boca?
• Beneficiário: Thaís Priscila Biassi
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 07/04907-0 - VEGF-C e densidade de vasos linfáticos em carcinoma espinocelular de boca: associação com as metástases linfonodais ocultas e com o prognóstico dos pacientes
• Beneficiário: Simone Eloiza Sita Faustino
• Modalidade de apoio: Bolsas no Brasil - Doutorado