Expression of laminin-5 and integrins in actinic cheilitis and superficially invasive squamous cell carcinomas of the lip

Autor(es)

da-Silva, Janaina Peixoto ^[1] ; Lourenco, Silvia ^[2] ; Nico, Marcello ^[3] ; Silva, Filomena H. ^[1] ; Martins, Marilia Trierveiler ^[4] ; Costa-Neves, Adriana ^[1]

Afiliação do(s) autor(es)

^[1] Butantan Inst, Cellular Biol Lab, BR-05503900 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Dent, Dept Gen Pathol, BR-05508 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Med, Dept Dermatol, BR-05508 Sao Paulo - Brazil

^[4] Univ Sao Paulo, Sch Dent, Dept Oral Pathol, BR-05508 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PATHOLOGY RESEARCH AND PRACTICE; v. 208, n. 10, p. 598-603, 2012.
• Citações Web of Science: 4

Resumo

The progression of carcinogenesis entails the detachment of cells, invasion and migration of neoplastic cells. Alterations in epithelial adhesion and basement membrane proteins might mediate the early stages of carcinogenesis. This study investigated the expression of adhesion molecules and the basement membrane protein laminin-5 in actinic cheilitis (AC) and incipient squamous cell carcinoma of the lower lip to understand early photocarcinogenesis. Ln-5 gamma 2 chain as well as alpha 3, beta 1 subunits of alpha 3 beta 1 heterodimer and beta 4 subunit of integrin alpha 6 beta 4 were evaluated by immunohistochemistry in 16 cases of AC and 16 cases of superficially invasive squamous cell carcinoma (SISCC). Most AC cases showed reduced expression of beta 1, beta 4 and alpha 3 integrins, and SISCCs lacked beta 1, beta 4 and alpha 3 integrins in the invasive front. AC cases were negative for the Ln-5 gamma 2 chain. Five cases of SISCC (31%) showed heterogeneous Ln-5 gamma 2 chain expression in the invasive front of the tumor. Integrin beta 1, beta 4 and alpha 3 expression is lost during the early stages of lip carcinogenesis. Expression of Ln-5 gamma 2 in the invasive front in cases and its correlation with tumor progression suggest that it mediates the acquisition of the migrating and invading epithelial cell phenotype. (C) 2012 Elsevier GmbH. All rights reserved. (AU)

• Processo FAPESP: 06/57365-7 - Estudo da distribuicao e expressao das integrinas, de componentes da matriz extracelular e da ciclina d1, na quelite actinica e no carcinoma epidermoide de labio humano.
• Beneficiário: Adriana da Costa Neves
• Modalidade de apoio: Auxílio à Pesquisa - Regular