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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Expression of laminin-5 and integrins in actinic cheilitis and superficially invasive squamous cell carcinomas of the lip

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Author(s):
da-Silva, Janaina Peixoto [1] ; Lourenco, Silvia [2] ; Nico, Marcello [3] ; Silva, Filomena H. [1] ; Martins, Marilia Trierveiler [4] ; Costa-Neves, Adriana [1]
Total Authors: 6
Affiliation:
[1] Butantan Inst, Cellular Biol Lab, BR-05503900 Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Dent, Dept Gen Pathol, BR-05508 Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Med, Dept Dermatol, BR-05508 Sao Paulo - Brazil
[4] Univ Sao Paulo, Sch Dent, Dept Oral Pathol, BR-05508 Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: PATHOLOGY RESEARCH AND PRACTICE; v. 208, n. 10, p. 598-603, 2012.
Web of Science Citations: 4
Abstract

The progression of carcinogenesis entails the detachment of cells, invasion and migration of neoplastic cells. Alterations in epithelial adhesion and basement membrane proteins might mediate the early stages of carcinogenesis. This study investigated the expression of adhesion molecules and the basement membrane protein laminin-5 in actinic cheilitis (AC) and incipient squamous cell carcinoma of the lower lip to understand early photocarcinogenesis. Ln-5 gamma 2 chain as well as alpha 3, beta 1 subunits of alpha 3 beta 1 heterodimer and beta 4 subunit of integrin alpha 6 beta 4 were evaluated by immunohistochemistry in 16 cases of AC and 16 cases of superficially invasive squamous cell carcinoma (SISCC). Most AC cases showed reduced expression of beta 1, beta 4 and alpha 3 integrins, and SISCCs lacked beta 1, beta 4 and alpha 3 integrins in the invasive front. AC cases were negative for the Ln-5 gamma 2 chain. Five cases of SISCC (31%) showed heterogeneous Ln-5 gamma 2 chain expression in the invasive front of the tumor. Integrin beta 1, beta 4 and alpha 3 expression is lost during the early stages of lip carcinogenesis. Expression of Ln-5 gamma 2 in the invasive front in cases and its correlation with tumor progression suggest that it mediates the acquisition of the migrating and invading epithelial cell phenotype. (C) 2012 Elsevier GmbH. All rights reserved. (AU)