Outbreak of carbapenem-resistant Klebsiella pneumoniae: two-year epidemiologic follow-up in a tertiary hospital

Autor(es)

Pereira, Graziella Hanna ^[1] ; Garcia, Doroti O. ^[2] ; Mostardeiro, Marcelo ^[1] ; Fanti, Karina S. V. N. ^[1] ; Levin, Anna S. ^[3]

Afiliação do(s) autor(es)

^[1] Hosp Brigadeiro, Dept Controle Infeccao, Sao Paulo, SP - Brazil

^[2] Adolfo Lutz Inst, Ctr Bacteriol, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Fac Med, Hosp Clin, Lab Invest Med, Dept Doencas Infecciosas & Parasit, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Memórias do Instituto Oswaldo Cruz; v. 108, n. 1, p. 113-115, FEB 2013.
• Citações Web of Science: 7

Resumo

This study describes a carbapenem-resistant Klebsiella pneumoniae (CRKP) outbreak that occurred from October 2008-December 2010. Polymerase chain reaction assays were performed to detect the blaKPC gene and molecular typing was performed using pulsed-field gel electrophoresis (PFGE). There were 33 CRKP infections; PFGE revealed five genotypes: genotype A in five (15%), B in 18 (55%), C in eight (24%) and two unique profiles. Genotype B was disseminated in all hospital units and belonged to the same clone identified in 11 different hospitals in the state of São Paulo. Sixteen (48%) patients died. Seven isolates (21%) were resistant to polymyxin B and 45% were resistant to tigecycline and amikacin. (AU)

• Processo FAPESP: 09/53229-0 - Detecção de genes de resistência produzidos por Klebsiella pneumoniae isolados de colonização e/ou infecção hospitalar
• Beneficiário: Doroti de Oliveira Garcia
• Modalidade de apoio: Auxílio à Pesquisa - Pesquisa em Políticas Públicas para o SUS