Effect of dopamine and serotonin receptor antagonists on fencamfamine-induced abolition of latent inhibition

Autor(es)

Ramos Alves de Aguiar, Cilene Rejane ^[1] ; Lima de Aguiar, Marlison Jose ^[2] ; DeLucia, Roberto ^[3] ; Araujo Silva, Maria Teresa ^[4]

Afiliação do(s) autor(es)

^[1] Univ Fed Pernambuco, CFCH, Lab Expt Psychol LABPEX, Dept Psychol, BR-50670901 Recife, PE - Brazil

^[2] Fac Integrada Vitoria de Santo Antao, Dept Psychol, BR-55610100 Vitoria De Santo Antao, PE - Brazil

^[3] Univ Sao Paulo, Inst Biomed Sci, BR-05585900 Sao Paulo - Brazil

^[4] Univ Sao Paulo, Inst Psychol, Dept Expt Psychol, BR-05508900 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: European Journal of Pharmacology; v. 698, n. 1-3, p. 246-251, JAN 5 2013.
• Citações Web of Science: 1

Resumo

The purpose of this investigation was to verify the role of dopamine and serotonin receptors in the effect of fencamfamine (FCF) on latent inhibition. FCF is a psychomotor stimulant with an indirect dopaminergic action. Latent inhibition is a model of attention. Latent inhibition is blocked by dopaminergic agents and facilitated by dopamine receptor agonists. FCF has been shown to abolish latent inhibition. The serotonergic system may also participate in the neurochemical mediation of latent inhibition. The selective dopamine D-1 receptor antagonist SCH 23390 (7-chloro-3-methyl-1-phenyl-1,2,4,5-tetrahydro-3-benzazepin-8-ol), D-2 receptor antagonists pimozide (PIM) and methoclopramide (METH), and serotonin 5-HT (2A/C) receptor antagonist ritanserin (RIT) were used in the present study. Latent inhibition was evaluated using a conditioned emotional response procedure. Male Wistar rats that were water-restricted were subjected to a three-phase procedure: preexposure to a tone, tone-shock conditioning, and a test of the effect of the tone on licking frequency. All of the drugs were administered before the preexposure and conditioning phases. The results showed that FCF abolished latent inhibition, and this effect was clearly antagonized by PIM and METH and moderately attenuated by SCH 23390. At the doses used in the present study, RIT pretreatment did not affect latent inhibition and did not eliminate the effect of FCF, suggesting that the FCF-induced abolition of latent inhibition is not mediated by serotonin 5-HT (2A/C) receptors. These results suggest that the effect of FCF on latent inhibition is predominantly related to dopamine D-2 receptors and that dopamine D-2 receptors participate in attention processes. (c) 2012 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 98/15315-5 - Efeito de bloqueadores dopaminérgicos e serotonérgicos sobre a abolição da inibição latente induzida por fencanfamina
• Beneficiário: Cilene Rejane Ramos Alves
• Modalidade de apoio: Bolsas no Brasil - Doutorado