Enhanced depth imaging optical coherence tomography in long-standing Vogt-Koyanagi-Harada disease

Autor(es)

da Silva, Felipe Theodoro ^[1] ; Sakata, Viviane Mayumi ^[1] ; Nakashima, Aloisio ^[1] ; Hirata, Carlos Eduardo ^[1] ; Olivalves, Edilberto ^[1] ; Takahashi, Walter Yukihiko ^[1] ; Costa, Rogerio Alves ^{[2, 3]} ; Yamamoto, Joyce Hisae ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med, Dept Ophthalmol, Uveitis Serv, Hosp Clin, BR-05019000 Sao Paulo - Brazil

^[2] Ctr Brasileiro Ciencias Visuais, Div Macula Imaging & Treatment, Belo Horizonte, MG - Brazil

^[3] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Ophthalmol, BR-05019000 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: BRITISH JOURNAL OF OPHTHALMOLOGY; v. 97, n. 1, p. 70-74, JAN 2013.
• Citações Web of Science: 45

Resumo

Aim To evaluate the choroidal thickness (CT) in patients with long-standing Vogt-Koyanagi-Harada (VKH) disease using enhanced depth imaging optical coherence tomography (EDI-OCT). Methods A prospective case-control study developed at a tertiary centre at Sao Paulo, Brazil. EDI-OCT images were obtained in 16 patients (30 eyes) with VKH disease who had had the disease for more than 6 months since disease onset, and in 17 normal individuals controlled by age (32 eyes). Comprehensive ophthalmic examination and EDI-OCT evaluation were performed. CT was measured at the fovea and at 1000 mu m intervals from the foveal centre in both temporal and nasal directions. CT was correlated with disease duration, clinical disease activity and fundus-based disease severity. Results Mean subfoveal CT was 333 mu m (+/- 85.8) in controls and 250.7 mu m (+/- 93.3) in VKH patients (p=0.002). The choroid was significantly thinner in patients when compared to controls in all but one nasal point. In patients, the CT measurements at the foveal centre presented a negative correlation with disease duration (p<0.001). No significant difference in CT measurements was observed between eyes with and without clinical inflammation (p=0.42). There was a trend towards more severe fundus changes being associated with a thinner choroid (p=0.28). Conclusions Patients with VKH and long-standing disease had thinner choroids when compared to controls. Progressive choroidal thinning related to disease duration was observed at the macula of these patients. Whether this finding is part of the natural history of the disease or the result of a clinically undetected choroidal inflammation remains to be determined. (AU)

• Processo FAPESP: 07/57154-9 - Função visual em pacientes com doença Vogt-Koyanagi-Harada: fase crônica
• Beneficiário: Felipe Theodoro Bezerra Gaspar Carvalho da Silva
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 07/57155-5 - Função visual em pacientes com Doença de Vogt-Koyanagi-Harada fase crônica
• Beneficiário: Joyce Hisae Yamamoto Takiuti
• Modalidade de apoio: Auxílio à Pesquisa - Regular