Prenatal testosterone exposure as a model for the study of endocrine-disrupting chemicals on the gerbil prostate

Autor(es)

Biancardi, Manoel F. ^[1] ; Perez, Ana P. S. ^[1] ; Goes, Rejane M. ^[2] ; Santos, Fernanda C. A. ^[3] ; Vilamaior, Patricia S. L. ^[4] ; Taboga, Sebastiao R. ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Inst Biol, Dept Cell Biol, BR-13084864 Sao Paulo - Brazil

^[2] Sao Paulo State Univ, IBILCE, Dept Biol, Lab Microscopy & Microanal, UNESP, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil

^[3] Univ Fed Goias, Dept Morphol, BR-74001970 Goiania, Go - Brazil

^[4] Rio Preto Univ Ctr UNIRP, Biol Sci & Vet Med Sch, BR-15025400 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Experimental Biology and Medicine; v. 237, n. 11, p. 1298-1309, NOV 2012.
• Citações Web of Science: 10

Resumo

The development of the prostate depends on a precise androgenic control, so sensible interferences may predispose this gland to develop prostatic diseases during life. These aspects are of interest and preoccupation, since human beings are exposed to a growing number of endocrine-disrupting chemicals with androgenic potential. Therefore, our aim was to evaluate the prostates of adult gerbils exposed to testosterone during intrauterine life. Serological, morphological, morphometric-stereologic, immunohistochemical and three-dimensional reconstruction analyses were used. We found that the testosterone effects were dose-dependent and more harmful to females, leading to the development of masculine characteristics, evidenced by an increased anogenital distance, and absence of vaginal opening and the ectopic development of prostatic tissue. Moreover, premalignant lesions, such as prostatic intraepithelial neoplasia, were observed in addition to inflammatory foci in the prostate. The results showed that the prenatal exposure to testosterone may affect the reproductive system, disrupting developmental processes and increasing susceptibility to the development of prostatic diseases in the Mongolian gerbil. (AU)

• Processo FAPESP: 07/06862-3 - Desenvolvimento da próstata masculina e feminina do gerbilo da Mongólia sob efeito da exposição intra-uterina e pós-natal de testosterona
• Beneficiário: Manoel Francisco Biancardi
• Modalidade de apoio: Bolsas no Brasil - Mestrado