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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

A School-Based Human Papillomavirus Vaccination Program in Barretos, Brazil: Final Results of a Demonstrative Study

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Autor(es):
Tavares Guerreiro Fregnani, Jose Humberto [1, 2] ; Carvalho, Andre Lopes [1] ; Eluf-Neto, Jose [2, 3] ; Braga Ribeiro, Karina de Cassia [2, 4] ; Kuil, Larissa de Melo [1] ; da Silva, Tauana Arcadepani [1] ; Rodrigues, Silvia Lapola [1] ; Mauad, Edmundo Carvalho [1] ; Longatto-Filho, Adhemar [1, 2, 5] ; Villa, Luisa Lina [2]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Barretos Canc Hosp IEP HCB, Res & Teaching Inst, Barretos - Brazil
[2] Santa Casa Sao Paulo Med Sch FCMSCSP, Natl Inst Sci & Technol Dis Associated Papillomav, Sao Paulo - Brazil
[3] Univ Sao Paulo, Fac Med, Dept Prevent Med, BR-09500900 Sao Paulo - Brazil
[4] Santa Casa Sao Paulo Med Sch FCMSCSP, Dept Social Med, Sao Paulo - Brazil
[5] Univ Sao Paulo, Sch Med, Med Res Lab 14, BR-09500900 Sao Paulo - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: PLoS One; v. 8, n. 4 APR 24 2013.
Citações Web of Science: 22
Resumo

Introduction: The implementation of a public HPV vaccination program in several developing countries, especially in Latin America, is a great challenge for health care specialists. Aim: To evaluate the uptake and the three-dose completion rates of a school-based HPV vaccination program in Barretos (Brazil). Methods: The study included girls who were enrolled in public and private schools and who regularly attended the sixth and seventh grades of elementary school (mean age: 11.9 years). A meeting with the parents or guardians occurred approximately one week before the vaccination in order to explain the project and clarify the doubts. The quadrivalent vaccine was administered using the same schedule as in the product package (0-2-6 months). The school visits for regular vaccination occurred on previously scheduled dates. The vaccine was also made available at Barretos Cancer Hospital for the girls who could not be vaccinated on the day when the team visited the school. Results: Among the potential candidates for vaccination (n = 1,574), the parents or guardians of 1,513 girls (96.1%) responded to the invitation to participate in the study. A total of 1,389 parents or guardians agreed to participate in the program (acceptance rate = 91.8%). The main reason for refusing to participate in the vaccination program was fear of adverse events. The vaccine uptake rates for the first, second, and third doses were 87.5%, 86.3% and 85.0%, respectively. The three-dose completion rate was 97.2%. Conclusions: This demonstrative study achieved high rates of vaccination uptake and completion of three vaccine doses in children 10-16 years old from Brazil. The feasibility and success of an HPV vaccination program for adolescents in a developing country may depend on the integration between the public health and schooling systems. (AU)

Processo FAPESP: 08/57889-1 - Instituto de Ciência e Tecnologia para o Estudo das Doenças Associadas ao Papilomavírus
Beneficiário:Luisa Lina Villa
Modalidade de apoio: Auxílio à Pesquisa - Temático