Autor(es)

Birsoy, Kivanc ^[1] ; Festuccia, William T. ^[2] ; Laplante, Mathieu ^[3]

Afiliação do(s) autor(es)

^[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 - USA

^[2] Univ Sao Paulo, Inst Biomed Sci, BR-05508000 Sao Paulo - Brazil

^[3] Univ Laval, Fac Med, CRIUCPQ, Ste Foy, PQ G1V 4G5 - Canada

• Tipo de documento: Artigo Científico
• Fonte: Journal of Cell Science; v. 126, n. 7, p. 1541-1552, APR 1 2013.
• Citações Web of Science: 36

Resumo

Lipid storage is an evolutionary conserved process that exists in all organisms from simple prokaryotes to humans. In Metazoa, long-term lipid accumulation is restricted to specialized cell types, while a dedicated tissue for lipid storage (adipose tissue) exists only in vertebrates. Excessive lipid accumulation is associated with serious health complications including insulin resistance, type 2 diabetes, cardiovascular diseases and cancer. Thus, significant advances have been made over the last decades to dissect out the molecular and cellular mechanisms involved in adipose tissue formation and maintenance. Our current understanding of adipose tissue development comes from in vitro cell culture and mouse models, as well as recent approaches to study lipid storage in genetically tractable lower organisms. This Commentary gives a comparative insight into lipid storage in uni- and multi-cellular organisms with a particular emphasis on vertebrate adipose tissue. We also highlight the molecular mechanisms and nutritional signals that regulate the formation of mammalian adipose tissue. (AU)

• Processo FAPESP: 10/52191-6 - Envolvimento dos sensores de nutrientes mTOR e PPARgama no início, manutenção e término da inflamação associada à obesidade e resistência à insulina
• Beneficiário: William Tadeu Lara Festuccia
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 09/15354-7 - Envolvimento do tecido adiposo no desenvolvimento da obesidade e patologias associadas: investigação dos mecanismos moleculares e busca de novas alternativas terapêuticas
• Beneficiário: William Tadeu Lara Festuccia
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores