Immunolocalization of podoplanin in benign odontogenic tumours with and without ectomesenchyme

Autor(es)

Caetano, Adriana dos Santos ^[1] ; Tjioe, Kellen Cristine ^[1] ; Sita Faustino, Simone Eloiza ^[1] ; Costa Hanemann, Joao Adolfo ^[2] ; Fernandes Belone, Andrea de Faria ^[3] ; Soares, Cleverson Teixeira ^[3] ; Oliveira, Denise Tostes ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Stomatol, Area Pathol, Bauru Sch Dent, Sao Paulo - Brazil

^[2] Alfenas Fed Univ, Dept Clin & Surg, Sch Dent, Alfenas, MG - Brazil

^[3] Lauro de Souza Lima Inst, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ARCHIVES OF ORAL BIOLOGY; v. 58, n. 4, p. 408-415, APR 2013.
• Citações Web of Science: 11

Resumo

Objectives: To investigate podoplanin expression in epithelial odontogenic tumours with and without ectomesenchyme and verify the association between its immunoexpression and proliferative activity in keratocystic odontogenic tumours (KCOTS) and orthokeratinized odontogenic cysts (OOCs). Design: Eight ameloblastomas, nine adenomatoid odontogenic tumours, twenty KCOTS, five OOC, one calcifying epithelial odontogenic tumour, two ameloblastic fibromas, four ameloblastic fibro-odontomas and five calcifying cystic odontogenic tumours were immunohistochemically analysed with anti-podoplanin antibody. For KCOTS and OOC, the cell proliferation index was determined with Ki-67 immunostaining and compared by Spearman correlation coefficient. Results: Podoplanin was expressed in the peripheral odontogenic epithelium of most tumours. Ectomesenchyme was negative, except for odontoblasts. KCOTS exhibited positive podoplanin expression while in OOC it was absent/weak. There was statistically significant correlation (p = 0.006) between podoplanin expression and cellular proliferation index of KCOTS and OOC. Conclusion: Podoplanin seems to be related to the proliferative activity of KCOTS and may have a role in the process of local invasion of odontogenic tumours with and without ectomesenchyme. (C) 2012 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 05/04577-4 - Influência do VEGF-C e da densidade de vasos linfáticos nas metástases linfonodais e no prognóstico de pacientes com carcinoma espinocelular de boca
• Beneficiário: Denise Tostes Oliveira
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 07/04907-0 - VEGF-C e densidade de vasos linfáticos em carcinoma espinocelular de boca: associação com as metástases linfonodais ocultas e com o prognóstico dos pacientes
• Beneficiário: Simone Eloiza Sita Faustino
• Modalidade de apoio: Bolsas no Brasil - Doutorado