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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Immunolocalization of podoplanin in benign odontogenic tumours with and without ectomesenchyme

Full text
Author(s):
Caetano, Adriana dos Santos [1] ; Tjioe, Kellen Cristine [1] ; Sita Faustino, Simone Eloiza [1] ; Costa Hanemann, Joao Adolfo [2] ; Fernandes Belone, Andrea de Faria [3] ; Soares, Cleverson Teixeira [3] ; Oliveira, Denise Tostes [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Dept Stomatol, Area Pathol, Bauru Sch Dent, Sao Paulo - Brazil
[2] Alfenas Fed Univ, Dept Clin & Surg, Sch Dent, Alfenas, MG - Brazil
[3] Lauro de Souza Lima Inst, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: ARCHIVES OF ORAL BIOLOGY; v. 58, n. 4, p. 408-415, APR 2013.
Web of Science Citations: 11
Abstract

Objectives: To investigate podoplanin expression in epithelial odontogenic tumours with and without ectomesenchyme and verify the association between its immunoexpression and proliferative activity in keratocystic odontogenic tumours (KCOTS) and orthokeratinized odontogenic cysts (OOCs). Design: Eight ameloblastomas, nine adenomatoid odontogenic tumours, twenty KCOTS, five OOC, one calcifying epithelial odontogenic tumour, two ameloblastic fibromas, four ameloblastic fibro-odontomas and five calcifying cystic odontogenic tumours were immunohistochemically analysed with anti-podoplanin antibody. For KCOTS and OOC, the cell proliferation index was determined with Ki-67 immunostaining and compared by Spearman correlation coefficient. Results: Podoplanin was expressed in the peripheral odontogenic epithelium of most tumours. Ectomesenchyme was negative, except for odontoblasts. KCOTS exhibited positive podoplanin expression while in OOC it was absent/weak. There was statistically significant correlation (p = 0.006) between podoplanin expression and cellular proliferation index of KCOTS and OOC. Conclusion: Podoplanin seems to be related to the proliferative activity of KCOTS and may have a role in the process of local invasion of odontogenic tumours with and without ectomesenchyme. (C) 2012 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 05/04577-4 - Influence of VEGF-C and lymphatic vessel density on regional metastasis and prognosis of patients with oral squamous cell carcinoma
Grantee:Denise Tostes Oliveira
Support Opportunities: Regular Research Grants
FAPESP's process: 07/04907-0 - VEGF-C and lymphatic vessel density in oral squamous cell carcinoma: association with occult lymph node metastases and patients' prognosis
Grantee:Simone Eloiza Sita Faustino
Support Opportunities: Scholarships in Brazil - Doctorate