Paepalanthus spp: Antimycobacterial activity of extracts, methoxylated flavonoids and naphthopyranone fractions

Autor(es)

Moreira, Raquel R. D. ^[1] ; Martins, Gilmarcio Z. ^[1] ; Pietro, Rosemeire C. L. R. ^[1] ; Sato, Daisy N. ^[1] ; Pavan, Fernando R. ^[1] ; Leite, Sergio R. A. ^[2] ; Vilegas, Wagner ^[2] ; Leite, Clarice Q. F. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estado Sao Paulo, Fac Ciencias Farmaceut, BR-14801502 Araraquara, SP - Brazil

^[2] Univ Estado Sao Paulo, Inst Quim, BR-14801502 Araraquara, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY; v. 23, n. 2, p. 268-272, MAR-APR 2013.
• Citações Web of Science: 5

Resumo

Paepalanthus spp., Eriocaulaceae, are native plants from Brazil known as ``sempre-vivas{''} (everlasting flowers). In this work, we evaluated the potential anti-mycobacterial activity of two methoxylated flavonoids (flavonoid 7-methylquercetagetin and 7-methylquercetagetin-4'-O-beta-D-glucopyranoside) isolated and identified from P. latipes and the naphthopyranone fractions from P. bromeliodes ethanolic extracts. The MIC value of 500 mu g/mL was verified for all compounds tested against M. tuberculosis H37Rv. For M. avium, the MIC value ranged from 1000-2000 mu g/mL excepting to naphthopyranone fractions with MIC of 500 mu g/mL. This is the first report of activity determination of Paepalanthus spp. flavonoids activity against Mycobacterium tuberculosis and M. avium. (AU)

• Processo FAPESP: 11/11593-7 - Pesquisa de novos fármacos contra tuberculose: implementação laboratorial para realizar ensaios pré-clínicos
• Beneficiário: Fernando Rogério Pavan
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 08/10390-2 - Determinação do perfil pré-clínico da atividade antituberculose in vitro e in vivo dos complexos de rutênio(II)fosfinas / diiminas
• Beneficiário: Fernando Rogério Pavan
• Modalidade de apoio: Bolsas no Brasil - Doutorado