| Full text | |
| Author(s): |
Moreira, Raquel R. D.
[1]
;
Martins, Gilmarcio Z.
[1]
;
Pietro, Rosemeire C. L. R.
[1]
;
Sato, Daisy N.
[1]
;
Pavan, Fernando R.
[1]
;
Leite, Sergio R. A.
[2]
;
Vilegas, Wagner
[2]
;
Leite, Clarice Q. F.
[1]
Total Authors: 8
|
| Affiliation: | [1] Univ Estado Sao Paulo, Fac Ciencias Farmaceut, BR-14801502 Araraquara, SP - Brazil
[2] Univ Estado Sao Paulo, Inst Quim, BR-14801502 Araraquara, SP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY; v. 23, n. 2, p. 268-272, MAR-APR 2013. |
| Web of Science Citations: | 5 |
| Abstract | |
Paepalanthus spp., Eriocaulaceae, are native plants from Brazil known as ``sempre-vivas{''} (everlasting flowers). In this work, we evaluated the potential anti-mycobacterial activity of two methoxylated flavonoids (flavonoid 7-methylquercetagetin and 7-methylquercetagetin-4'-O-beta-D-glucopyranoside) isolated and identified from P. latipes and the naphthopyranone fractions from P. bromeliodes ethanolic extracts. The MIC value of 500 mu g/mL was verified for all compounds tested against M. tuberculosis H37Rv. For M. avium, the MIC value ranged from 1000-2000 mu g/mL excepting to naphthopyranone fractions with MIC of 500 mu g/mL. This is the first report of activity determination of Paepalanthus spp. flavonoids activity against Mycobacterium tuberculosis and M. avium. (AU) | |
| FAPESP's process: | 11/11593-7 - Research for new drugs against tuberculosis: laboratory improvement to perform pre-clinical trials |
| Grantee: | Fernando Rogério Pavan |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 08/10390-2 - Determination of pre-clinical profile in vitro and in vivo anti-tuberculosis activity of ruthenium(II)phosphine / picolinate complexes |
| Grantee: | Fernando Rogério Pavan |
| Support Opportunities: | Scholarships in Brazil - Doctorate |