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Chemical study of the extracts produced by endophytic fungi associated with the aerial parts of Eriocaulaceae species and its antimicrobial activity

Grant number: 15/04899-3
Support type:Regular Research Grants
Duration: July 01, 2015 - June 30, 2017
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Lourdes Campaner dos Santos
Grantee:Lourdes Campaner dos Santos
Home Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil


In the research project finished referring to the period (2012-2014- Fapesp n. 2012/03882-1)) were carried out chemical studies with the species Paepalanthus geniculatus, Tonina fluviatilis, Paepalanthus chiquitensis (synonym of Paepalanthus giganteus Sano). Studies of plant species Actinocephalus divaricatus were initiated. During the project development period, twelve papers were presented in National and International Congresses, nine papers were published in international and national Journals. Currently, are directly involved in the Project, four Master's projects and Scientific one Initiation. Two Master and four scientific Iniciation projects were carried out through grants FAPESP, CAPES and CNPq.Therefore, this project proposes to continue the study of Eriocaulaceae, but by entering the search of secondary active metabolites produced by endophytic fungi associated with aerial parts (leaves, scapes and capitulae) of the species Eriocaulaceae, starting with the species (Paepalanthus chiquitensis and Paepalanthus planifolius).Considering the current importance and relevance of natural products from fungi, we are implementing in our group, the chemical study of endophytic fungi associated with Eriocaulaceae. Knowledge of metabolites from the endophytic fungi greatly complements theThe purpose of this project is therefore perform antimicrobial and antifungal testing of ethyl acetate extracts of the aerial parts produced by endophytic fungi, starting with the species P. planifolius and P. chiquitensis. Other species may be included in the project depending on the progress and completion of studies of the species started.The criteria for selection of the extracts to be studied, and therefore be prepared on a large scale, will be the best antimicrobial and antifungal activities and those who have a higher amount of mass for purification of secondary metabolites. extensive phytochemical work that is being done for us over the past few years.The fingerprints will be recorded by HPLC-PDA, 1 H NMR and HPLC-ESI-IT-MS. The known substances shall be identified with co-injection of standards and for substances not yet isolated and identified in the literature, fractionation and purification will be achieved by chromatographic methods (Sephadex LH-20, HPLC, MPLC). The identification of substances is performed by spectroscopic and spectrometric (MS, IR, UV, NMR). Also will be made antimicrobial and fungicidal activities of the enriched fractions and pure substances can be conducted. (AU)

Scientific publications (9)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
HILARIO, FELIPE; POLINARIO, GIULIA; DE AMORIM, MARCELO RODRIGUES; BATISTA, VICTOR DE SOUSA; DO NASCIMENTO JUNIOR, NAILTON MONTEIRO; ARAUJO, ANGELA REGINA; BAUAB, TAIS MARIA; DOS SANTOS, LOURDES CAMPANER. Spirocyclic lactams and curvulinic acid derivatives from the endophytic fungus Curvularia lunata and their antibacterial and antifungal activities. Fitoterapia, v. 141, MAR 2020. Web of Science Citations: 0.
BOTERO, WESLEI BRUNO; DE AMORIM, MARCELO R.; CARLOS, IRACILDA Z.; POLESI, MARISA C.; DOS SANTOS, LOURDES C. Aromatic Polyketides and Macrolides from Microsphaeropsis arundinis. Journal of the Brazilian Chemical Society, v. 31, n. 2, p. 364-369, FEB 2020. Web of Science Citations: 0.
DE AMORIM, MARCELO R.; HILARIO, FELIPE; DOS SANTOS JUNIOR, FERNANDO M.; BATISTA JUNIOR, JOAOM.; BAUAB, TAIS M.; ARAUJO, ANGELA R.; CARLOS, IRACILDA Z.; VILEGAS, WAGNER; DOS SANTOS, LOURDES C. New Benzaldehyde and Benzopyran Compounds from the Endophytic Fungus Paraphaeosphaeria sp. F03 and Their Antimicrobial and Cytotoxic Activities {*}. Planta Medica, v. 85, n. 11/12, p. 957-964, AUG 2019. Web of Science Citations: 0.
VALERINO-DIAZ, ALEXANDER B.; GAMIOTEA-TURRO, DAYLIN; ZANATTA, ANA C.; VILEGAS, WAGNER; GOMES MARTINS, CARLOS HENRIQUE; SILVA, THAYNA DE SOUZA; RASTRELLI, LUCA; DOS SANTOS, LOURDES CAMPANER. New Polyhydroxylated Steroidal Saponins from Solanum paniculatum L. Leaf Alcohol Tincture with Antibacterial Activity against Oral Pathogens. Journal of Agricultural and Food Chemistry, v. 66, n. 33, p. 8703-8713, AUG 22 2018. Web of Science Citations: 2.
DE AMORIM, MARCELO R.; HILARIO, FELIPE; SANO, PAULO T.; BAUAB, TAIS M.; DOS SANTOS, LOURDES C. Antimicrobial Activity of Paepalanthus planifolius and its Major Components against Selected Human Pathogens. Journal of the Brazilian Chemical Society, v. 29, n. 4, p. 766-774, APR 2018. Web of Science Citations: 2.
ZANATTA, ANA C.; MARI, ANGELA; MASULLO, MILENA; CARLOS, IRACILDA ZEPPONE; VILEGAS, WAGNER; PIACENTE, SONIA; DOS SANTOS, LOURDES CAMPANER. Chemical metabolome assay by high-resolution Orbitrap mass spectrometry and assessment of associated antitumoral activity of Actinocephalus divaricatus. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, v. 32, n. 3, p. 241-250, FEB 15 2018. Web of Science Citations: 3.
GAMIOTEA-TURRO, DAYLIN; CAMAFORTE, NATHALIA A. P.; VALERINO-DIAZ, ALEXANDER B.; ORTIZ NUNEZ, YARELIS; RINALDO, DANIEL; DOKKEDAL, ANNE L.; BOSQUEIRO, JOSE R.; DOS SANTOS, LOURDES CAMPANER. Qualitative and Quantitative Analysis of Ethanolic Extract and Phenolic Fraction of Jatropha aethiopica (Euphorbiaceae) Leaves and Their Hypoglycemic Potential. Journal of Agricultural and Food Chemistry, v. 66, n. 6, p. 1419-1427, FEB 14 2018. Web of Science Citations: 2.
FELIPE HILÁRIO; VANESSA M. CHAPLA; ANGELA R. ARAUJO; PAULO T. SANO; TAÍS M. BAUAB; LOURDES C. DOS SANTOS. Antimicrobial Screening of Endophytic Fungi Isolated from the Aerial Parts of Paepalanthus chiquitensis (Eriocaulaceae) Led to the Isolation of Secondary Metabolites Produced by Fusarium fujikuroi. Journal of the Brazilian Chemical Society, v. 28, n. 8, p. 1389-1395, Ago. 2017. Web of Science Citations: 2.
DE AMORIM, MARCELO R.; SOMENSI, ANDRESSA; ARAUJO, ANGELA R.; BONIFACIO, BRUNA V.; BAUAB, TAIS M.; DOS SANTOS, LOURDES C. Compounds of Anthostomella brabeji, an Endophytic Fungus Isolated from Paepalanthus planifolius (Eriocaulaceae). Journal of the Brazilian Chemical Society, v. 27, n. 6, p. 1048-1054, JUN 2016. Web of Science Citations: 0.

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