Compounds of Anthostomella brabeji, an Endophytic Fungus Isolated from Paepalanthus planifolius (Eriocaulaceae)

Author(s)

de Amorim, Marcelo R. ^[1] ; Somensi, Andressa ^[1] ; Araujo, Angela R. ^[1] ; Bonifacio, Bruna V. ^[2] ; Bauab, Tais M. ^[2] ; dos Santos, Lourdes C. ^[1]

Affiliation

^[1] Univ Estadual Paulista UNESP, Dept Quim Organ, Inst Quim, BR-14800900 Araraquara, SP - Brazil

^[2] Univ Estadual Paulista UNESP, Dept Ciencias Biol, Escola Ciencias Farmaceut, BR-14800900 Araraquara, SP - Brazil

• Document type: Journal article
• Source: Journal of the Brazilian Chemical Society; v. 27, n. 6, p. 1048-1054, JUN 2016.
• Web of Science Citations: 0

Abstract

In this study, fifteen endophytic fungi were isolated from Paepalanthus planifolius (Eriocaulaceae). From the capitula, seven endophytes were screened and evaluated for their metabolomic profile and radical scavenging activity (2,2-diphenyl-1-picrylhydrazyl (DPPH) assay). Chemical investigation of ethyl acetate extract of the endophytic fungus Anthostomella brabeji resulted in the isolation of one new compound, (+)-(6R*,7S*,8R*)-6,7,8-trihydroxy-2,2-dimethyl-5,6,7,8-tetrahydro-chroman-4-one, and three known compounds: 6-hydroxy-2,2-dimethyl-5,6,7,8-tetrahydro-7,8-epoxycroman-4-one, siccayne and eutypinol. All of the compound structures were elucidated using 1D and 2D nuclear magnetic resonance (NMR) and mass spectrometry (MS) analyses. The antimicrobial activity of the compounds and A. brabeji extract were assayed against the microorganisms Staphylococcus aureus, Escherichia coli, Salmonella setubal and Candida albicans. Measured minimal inhibitory concentration (MIC) values ranged from 31.25 to 1000.0 µg mL-1. (AU)

• FAPESP's process: 15/04899-3 - Chemical study of the extracts produced by endophytic fungi associated with the aerial parts of Eriocaulaceae species and its antimicrobial activity
• Grantee: Lourdes Campaner dos Santos
• Support Opportunities: Regular Research Grants