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Chemical and biological prospecting of endophytic fungi associated with Paepalanthus planifolius (Eriocaulaceae)

Grant number: 15/11058-5
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): March 01, 2016
Effective date (End): December 31, 2019
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal researcher:Lourdes Campaner dos Santos
Grantee:Marcelo Rodrigues de Amorim
Home Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Associated scholarship(s):18/05905-5 - Epigenetic modifiers: extending the metabolic diversity of endophytic fungi, BE.EP.DR


Considering the importance and relevance of natural products from endophytic fungi as promising sources of new drugs, this project proposes the search of bioactive secondary metabolites produced by endophytes associated with Paepalanthus planifolius belonging to Eriocaulaceae.The criteria for selection of endophytes for chemical study will be the biological screening (antitumor and antimicrobials tests) of the extracts produced in PDB liquid medium, on a reduced scale.The selected endophytes will be grown in small scale in differents cultures medium: liquids (PDB, Czapek, Malt Extract, Nutrient and YM) and solid (rice and corn) to obtain the crude extracts and assessment of the chemical profile and bioassays. After, the most promising extracts will be grown on an enlarged scale, fractionated and purified by chromatographics methods that demonstrate more appropriate (Sephadex LH-20, MPLC, HPLC) to obtain the pure substances. The elucidation of the substances or structural determination will be performed by spectroscopic and spectrometric methods (MS, IR, UV, NMR). Pure substances will be forwarded to the biological assays.During the development of the activities will be recorded "fingerprints" by HPLC-DAD, 1H NMR and HPLC-ESI-IT-MS of extracts, fractions and pure substances.This work aims to search for new bioactive agents and extend rational studies of the chemistry of endophytes associated to plant species Eriocaulaceae.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BOTERO, WESLEI BRUNO; DE AMORIM, MARCELO R.; CARLOS, IRACILDA Z.; POLESI, MARISA C.; DOS SANTOS, LOURDES C. Aromatic Polyketides and Macrolides from Microsphaeropsis arundinis. Journal of the Brazilian Chemical Society, v. 31, n. 2, p. 364-369, FEB 2020. Web of Science Citations: 0.
DE AMORIM, MARCELO R.; HILARIO, FELIPE; DOS SANTOS JUNIOR, FERNANDO M.; BATISTA JUNIOR, JOAOM.; BAUAB, TAIS M.; ARAUJO, ANGELA R.; CARLOS, IRACILDA Z.; VILEGAS, WAGNER; DOS SANTOS, LOURDES C. New Benzaldehyde and Benzopyran Compounds from the Endophytic Fungus Paraphaeosphaeria sp. F03 and Their Antimicrobial and Cytotoxic Activities {*}. Planta Medica, v. 85, n. 11/12, p. 957-964, AUG 2019. Web of Science Citations: 0.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
AMORIM, Marcelo Rodrigues de. Bioprospection of endophytic fungi Paraphaeosphaeria sporulosa and Cochliobolus eragrostidis isolated from Paepalanthus planifolius (Eriocaulaceae) and epigenetic study of Aspergillus terreus. 2019. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Instituto de Química. Araraquara Araraquara.

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