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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Spirocyclic lactams and curvulinic acid derivatives from the endophytic fungus Curvularia lunata and their antibacterial and antifungal activities

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Author(s):
Hilario, Felipe [1] ; Polinario, Giulia [1] ; de Amorim, Marcelo Rodrigues [2] ; Batista, Victor de Sousa [2] ; do Nascimento Junior, Nailton Monteiro [2] ; Araujo, Angela Regina [2] ; Bauab, Tais Maria [1] ; dos Santos, Lourdes Campaner [2]
Total Authors: 8
Affiliation:
[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Rd Araraquara Jau Km1, BR-14800903 Araraquara, SP - Brazil
[2] Sao Paulo State Univ UNESP, Inst Chem, Av Prof Francisco Degni 55, BR-14800060 Araraquara, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Fitoterapia; v. 141, MAR 2020.
Web of Science Citations: 0
Abstract

Curvularia lunata, isolated from the capitula of Paepalanthus chiquitensis (Eriocaulaceae), was cultured in potato dextrose broth (PDB) medium. The ethyl acetate extract yielded two new spirocyclic gamma-lactams (3 and 4), and five known compounds, namely: triticones E (1) and F (2), 5-O-methylcurvillinic acid (5), curvulinic acid (6) and curvulin (7). Their structures were elucidated by spectroscopic analysis and by the comparison with literature data. Besides, a computational study was used to elucidate the absolute configuration of the C - 3' in the compounds (3) and (4). The extract and the compounds (1 and 2), (6) and (7) were assayed against gram positive and gram-negative bacteria and fluconazole-resistant yeast. The triticones (1) and (2) showed good antibacterial activity for Escherichia coli, with a minimum inhibitory concentration of 62.5 mu g/mL. (AU)

FAPESP's process: 13/25432-0 - In vitro and in vivo anti-Candida albicans and anti-Helicobacter pylori activity of extracts of Astronium sp. incorporated or not into nanostructured systems
Grantee:Taís Maria Bauab
Support Opportunities: Regular Research Grants
FAPESP's process: 15/04899-3 - Chemical study of the extracts produced by endophytic fungi associated with the aerial parts of Eriocaulaceae species and its antimicrobial activity
Grantee:Lourdes Campaner dos Santos
Support Opportunities: Regular Research Grants
FAPESP's process: 18/00187-7 - Design, computational studies, synthesis and pharmacological evaluation of novel bioactive substances against nicotinic acetylcholine receptors alpha7 and alpha4beta2
Grantee:Nailton Monteiro Do Nascimento Júnior
Support Opportunities: Regular Research Grants