| Grant number: | 13/25432-0 |
| Support Opportunities: | Regular Research Grants |
| Start date: | April 01, 2014 |
| End date: | March 31, 2016 |
| Field of knowledge: | Health Sciences - Pharmacy |
| Principal Investigator: | Taís Maria Bauab |
| Grantee: | Taís Maria Bauab |
| Host Institution: | Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil |
| City of the host institution: | Araraquara |
Abstract
Brazil has one of the richest biodiversity and stand in a prime position, with around 25% of the world's flora. Additionally, the scientific community has become increasingly interested in medicinal plants and herbal medicines, because they are cheaper than the conventional therapy. Moreover, the irrational use of antimicrobial agents to treat these infections resulted in the emergence of multidrug-resistant strains, and thus increasing failures in drug treatment, which stimulates the use of alternative ways to control infectious diseases. The treatment of chronic diseases is urgent in the national and international context. Among these diseases, the ones that stand out are the diseases that affect the digestive tract (gastric and duodenal ulcers, ulcerative colitis and Crohn's disease), diabetes and cancer. The use of standardized herbal medicines effectively and safely has shown some amazing results to treat these diseases. In order to expand the studies of medicinal plants and contribute to the development of new drugs, an interdisciplinary group proposed the project "Standardized Herbal Medicines for the treatment of chronic diseases" in line with the National Policy of Medicinal Plants and Herbal medicines of the Ministry of Health. Among the plants which will be studied is the genus Astronium (Anacardiaceae) which has many medicinal plants, like A. urundeuva, A. fraxinifolium and A. graveolens. They are popularly used as antipyretics, antidiarrheals, anticancer and antimicrobial, properties attributed to the chemical components, like lignans, flavonoids, triterpenes. In this project, ethanolic extracts from the species A. urundeuva, A. fraxinifolium and A. graveolens will be studied, in order to determine the antimicrobial activity of these plant species using the microplate dilution technique for: Staphylococcus aureus, Escherichia coli, Salmonella sp, Helicobacter pylori and Candida albicans. After that, the extracts will be incorporated in microemulsion systems and re-evaluated for their antimicrobial activity. It is expected that in these formulations, the extracts have their activity increased, ensuring the development of an alternative and effective therapy with lower doses. Furthermore, in vivo assays will be performed in order to determine the anti - vulvovaginal candidiasis, anti-Helicobacter pylori and antiulcerogenic potential of these extracts loaded or not into the proposed systems. (AU)
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