Evaluation of the anti-Candida non-albicans potential of fractions of the methanolic extract of Syngonanthus nitens (Bong.) Ruhland incorporated and not incorporated in the nanostructured system

• Grant number: 17/18435-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): December 01, 2017
• Effective date (End): November 30, 2018
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Taís Maria Bauab
• Grantee: Laura Caminitti de Lima
• Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

Candida genus is the main cause of opportunistic diseases and potentially harmful to the health of the man, especially C. albicans, C. krusei, C. tropicalis, C. glabrata and C. parapsilosis. The mechanisms of virulence is complex, such as, biofilms formation, which generate difficulties in the treatment of the vulvovaginal candidiasis (CVV). Syngonanthus nitens has been shown to be important in the control of Candida species, and it is applicable to CVV therapy in our research group studies using the methanolic extract of scapes. Due to the benefits presented by this plant specie, it is relevant alternatives that increase the bioavailability, such as, the incorporation of the plant extract into a nanotechnology system for the release of drugs such as lipid carriers. The objective of this work will be to evaluate the behavior of the methanol extract of S. nitens scapes and five fractions isolated, not loaded form and loaded into a nanostructured lipid system in order to investigate the antifungal potential against C. krusei, C. tropicalis, C. glabrata and C. parapsilosis with resistance profile to azoes. Additionally, the inhibitory capacity of these plant derivatives in monotypic and heterotypic biofilms related to CVV will be evaluated, and the antifungal activity will be determined by microdilution. The fraction that to present the best activity, it will be loaded into lipid carrier. It is hoped to contribute to the applicability of the S. nitens plant extract against Candida species as well as to verify the possible application in the control or inhibition of the biofilms produced by these microorganisms. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE LIMA, LAURA C.; RAMOS, MATHEUS A. S.; DE TOLEDO, LUCIANI G.; RODERO, CAMILA F.; HILARIO, FELIPE; DOS SANTOS, LOURDES C.; CHORILLI, MARLUS; BAUAB, TAIS M.. Syngonanthus nitens (Bong.) Ruhland Derivatives Loaded into a Lipid Nanoemulsion for Enhanced Antifungal Activity Against Candida parapsilosis. CURRENT PHARMACEUTICAL DESIGN, v. 26, n. 14, p. 1556-1565, 2020. (18/23442-2, 17/18435-4)