Horizontal ridge augmentation of the atrophic anterior maxilla using rhBMP-2/ACS or autogenous bone grafts: a proof-of-concept randomized clinical trial

Autor(es)

de Freitas, Rubens Moreno ^{[1, 2, 3]} ; Susin, Cristiano ^{[2, 3, 4]} ; Spin-Neto, Rubens ^{[1, 5]} ; Marcantonio, Claudio ^[1] ; Wikesjoe, Ulf M. E. ^{[2, 3, 4]} ; Violin Dias Pereira, Luis Antonio ^[6] ; Marcantonio, Jr., Elcio ^[1]

Afiliação do(s) autor(es)

^[1] UNESP Univ Estadual Paulista, Araraquara Dent Sch, Dept Diag & Surg Periodont, BR-14801903 Araraquara, SP - Brazil

^[2] Coll Dent Med, Lab Appl Periodontal & Craniofacial Regenerat, Dept Periodont, Augusta, GA - USA

^[3] Coll Dent Med, Dept Oral Biol, Augusta, GA - USA

^[4] Georgia Regents Univ, Med Coll Georgia, Dept Orthoped, Augusta, GA - USA

^[5] Aarhus Univ, Dept Dent, Aarhus - Denmark

^[6] UNICAMP State Univ Campinas, Inst Biol, Dept Histol & Embryol, Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF CLINICAL PERIODONTOLOGY; v. 40, n. 10, p. 968-975, OCT 2013.
• Citações Web of Science: 45

Resumo

Aim: To compare the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) in an absorbable collagen sponge carrier (ACS) with autogenous bone graft for augmentation of the edentulous atrophic anterior maxilla. Methods: Twenty-four subjects were enrolled in a randomized, controlled, parallel-group, open-label clinical trial. Subjects either received rhBMP-2/ACS (1.5mg/ml) or particulated autogenous bone harvested from the mandibular retromolar region. A titanium-mesh was used to provide space and wound stability. A guide was used to standardize clinical recordings using an analogue caliper. Alveolar ridge width was also assessed using cone-beam computed tomography. Results: rhBMP-2/ACS yielded significantly greater radiographic horizontal bone gain compared with autogenous bone graft at immediate subcrestal levels (1.5 +/- 0.7 versus 0.5 +/- 0.9mm; p=0.01); non-significant differences were observed at mid- (2.9 +/- 0.8 versus 2.9 +/- 0.9mm; p=0.98) and apical (1.7 +/- 0.9 versus 1.8 +/- 1.1mm; p=0.85) crestal levels. No significant differences in clinical horizontal bone gain were observed at 6months between rhBMP-2/ACS and autogenous bone graft (3.2 +/- 0.9mm versus 3.7 +/- 1.4mm; p=0.31). Sixty-two implants were placed after 6month of healing with no significant differences between groups for number of implants, implant size, primary stability and survival. Conclusions: rhBMP-2/ACS appears a realistic alternative for augmentation of the edentulous atrophic anterior maxilla. (AU)

• Processo FAPESP: 09/16016-8 - Comparação entre enxerto ósseo autólogo e rhBMP-2 (infuse bone graft) na reconstrução de maxila atrófica anterior
• Beneficiário: Elcio Marcantonio Junior
• Modalidade de apoio: Auxílio à Pesquisa - Regular