Photodynamic therapy in the treatment of class II furcation: a randomized controlled clinical trial

Autor(es)

Luchesi, Vanessa H. ^[1] ; Pimentel, Suzana P. ^[1] ; Kolbe, Maria F. ^[1] ; Ribeiro, Fernanda V. ^[1] ; Casarin, Renato C. ^[1] ; Nociti, Jr., Francisco H. ^[2] ; Sallum, Enilson A. ^[2] ; Casati, Marcio Z. ^[1]

Afiliação do(s) autor(es)

^[1] Paulista Univ Sao Paulo, Sch Dent, Dent Res Div, Sao Paulo - Brazil

^[2] Univ Campinas UNICAMP, Sch Dent Piracicaba, Dept Prosthodont & Periodont, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF CLINICAL PERIODONTOLOGY; v. 40, n. 8, p. 781-788, AUG 2013.
• Citações Web of Science: 25

Resumo

Aim: To investigate the effect of photodynamic therapy (PDT) as adjunct to mechanical therapy in furcations. Materials and Methods: A double-blind, parallel, randomized controlled clinical trial was conducted in subjects presenting class II furcations. The subjects were randomly allocated to a test (PDT; n = 16) or control group (non-activated laser/only photosensitizer; n = 21). At baseline, 3 and 6 months, clinical, microbiological and cytokine pattern evaluation was performed. Clinical attachment level was defined as the primary outcome variable. Results: Clinical parameters improved after both therapies (p < 0.05) with no differences between groups at any time point (p > 0.05). At 6 months, real-time PCR evaluation showed a decrease in Porphyromonas gingivalis and Tannerella forsythia only in the PDT group (p < 0.05) with no inter-group differences. Regarding cytokines, IL-4 and IL-10 levels increased in both groups at 6 months. GM-CSF, IL-8, IL-1 beta and IL-6 levels decreased only in the PDT group after 3 months (p < 0.05). At 3 months, inter-group analyses showed that GM-CSF, IFN-gamma, IL-6 and IL-8 levels were lower in the PDT group. At 6 months, lower IL-1 beta levels were also observed in the PDT group (p < 0.05). Conclusion: Photodynamic therapy did not promote clinical benefits for class II furcations; however, advantages in local levels of cytokines and a reduction in periodontopathogens were demonstrated. (AU)

• Processo FAPESP: 10/51218-8 - Terapia fotodinamica no tratamento da doenca periodontal. avaliacao clinica, microbiologica e imunoenzimatica.
• Beneficiário: Márcio Zaffalon Casati
• Modalidade de apoio: Auxílio à Pesquisa - Regular