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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Photodynamic therapy in the treatment of class II furcation: a randomized controlled clinical trial

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Author(s):
Luchesi, Vanessa H. [1] ; Pimentel, Suzana P. [1] ; Kolbe, Maria F. [1] ; Ribeiro, Fernanda V. [1] ; Casarin, Renato C. [1] ; Nociti, Jr., Francisco H. [2] ; Sallum, Enilson A. [2] ; Casati, Marcio Z. [1]
Total Authors: 8
Affiliation:
[1] Paulista Univ Sao Paulo, Sch Dent, Dent Res Div, Sao Paulo - Brazil
[2] Univ Campinas UNICAMP, Sch Dent Piracicaba, Dept Prosthodont & Periodont, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: JOURNAL OF CLINICAL PERIODONTOLOGY; v. 40, n. 8, p. 781-788, AUG 2013.
Web of Science Citations: 25
Abstract

Aim: To investigate the effect of photodynamic therapy (PDT) as adjunct to mechanical therapy in furcations. Materials and Methods: A double-blind, parallel, randomized controlled clinical trial was conducted in subjects presenting class II furcations. The subjects were randomly allocated to a test (PDT; n = 16) or control group (non-activated laser/only photosensitizer; n = 21). At baseline, 3 and 6 months, clinical, microbiological and cytokine pattern evaluation was performed. Clinical attachment level was defined as the primary outcome variable. Results: Clinical parameters improved after both therapies (p < 0.05) with no differences between groups at any time point (p > 0.05). At 6 months, real-time PCR evaluation showed a decrease in Porphyromonas gingivalis and Tannerella forsythia only in the PDT group (p < 0.05) with no inter-group differences. Regarding cytokines, IL-4 and IL-10 levels increased in both groups at 6 months. GM-CSF, IL-8, IL-1 beta and IL-6 levels decreased only in the PDT group after 3 months (p < 0.05). At 3 months, inter-group analyses showed that GM-CSF, IFN-gamma, IL-6 and IL-8 levels were lower in the PDT group. At 6 months, lower IL-1 beta levels were also observed in the PDT group (p < 0.05). Conclusion: Photodynamic therapy did not promote clinical benefits for class II furcations; however, advantages in local levels of cytokines and a reduction in periodontopathogens were demonstrated. (AU)