Influence of probe pressure on the diffuse correlation spectroscopy blood flow signal: extra-cerebral contributions

Autor(es):Mostrar menos -

Mesquita, Rickson C. ^{[1, 2]} ; Schenkel, Steven S. ^[1] ; Minkoff, David L. ^[1] ; Lu, Xiangping ^[3] ; Favilla, Christopher G. ^[3] ; Vora, Patrick M. ^[1] ; Busch, David R. ^{[1, 4]} ; Chandra, Malavika ^[1] ; Greenberg, Joel H. ^[3] ; Detre, John A. ^{[3, 5]} ; Yodh, A. G. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Penn, Dept Phys & Astron, Philadelphia, PA 19104 - USA

^[2] Univ Estadual Campinas, Inst Phys, BR-13083859 Campinas, SP - Brazil

^[3] Univ Penn, Dept Neurol, Philadelphia, PA 19104 - USA

^[4] Childrens Hosp Philadelphia, Dept Pediat, Div Neurol, Philadelphia, PA 19104 - USA

^[5] Univ Penn, Dept Radiol, Philadelphia, PA 19104 - USA

• Tipo de documento: Artigo Científico
• Fonte: BIOMEDICAL OPTICS EXPRESS; v. 4, n. 7, p. 978-994, JUL 1 2013.
• Citações Web of Science: 25

Resumo

A pilot study explores relative contributions of extra-cerebral (scalp/skull) versus brain (cerebral) tissues to the blood flow index determined by diffuse correlation spectroscopy (DCS). Microvascular DCS flow measurements were made on the head during baseline and breath-holding/hyperventilation tasks, both with and without pressure. Baseline (resting) data enabled estimation of extra-cerebral flow signals and their pressure dependencies. A simple two-component model was used to derive baseline and activated cerebral blood flow (CBF) signals, and the DCS flow indices were also cross-correlated with concurrent Transcranial Doppler Ultrasound (TCD) blood velocity measurements. The study suggests new pressure-dependent experimental paradigms for elucidation of blood flow contributions from extra-cerebral and cerebral tissues. (C) 2013 Optical Society of America (AU)

• Processo FAPESP: 12/02500-8 - Desenvolvimento de instrumentação e metodologias para monitoramento de oxigenação, fluxo sanguíneo e metabolismo cerebral com espectroscopias ópticas de difusão
• Beneficiário: Rickson Coelho Mesquita
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores