Influence of probe pressure on the diffuse correlation spectroscopy blood flow signal: extra-cerebral contributions

Author(s):Show less -

Mesquita, Rickson C. ^{[1, 2]} ; Schenkel, Steven S. ^[1] ; Minkoff, David L. ^[1] ; Lu, Xiangping ^[3] ; Favilla, Christopher G. ^[3] ; Vora, Patrick M. ^[1] ; Busch, David R. ^{[1, 4]} ; Chandra, Malavika ^[1] ; Greenberg, Joel H. ^[3] ; Detre, John A. ^{[3, 5]} ; Yodh, A. G. ^[1]

Affiliation

^[1] Univ Penn, Dept Phys & Astron, Philadelphia, PA 19104 - USA

^[2] Univ Estadual Campinas, Inst Phys, BR-13083859 Campinas, SP - Brazil

^[3] Univ Penn, Dept Neurol, Philadelphia, PA 19104 - USA

^[4] Childrens Hosp Philadelphia, Dept Pediat, Div Neurol, Philadelphia, PA 19104 - USA

^[5] Univ Penn, Dept Radiol, Philadelphia, PA 19104 - USA

• Document type: Journal article
• Source: BIOMEDICAL OPTICS EXPRESS; v. 4, n. 7, p. 978-994, JUL 1 2013.
• Web of Science Citations: 25

Abstract

A pilot study explores relative contributions of extra-cerebral (scalp/skull) versus brain (cerebral) tissues to the blood flow index determined by diffuse correlation spectroscopy (DCS). Microvascular DCS flow measurements were made on the head during baseline and breath-holding/hyperventilation tasks, both with and without pressure. Baseline (resting) data enabled estimation of extra-cerebral flow signals and their pressure dependencies. A simple two-component model was used to derive baseline and activated cerebral blood flow (CBF) signals, and the DCS flow indices were also cross-correlated with concurrent Transcranial Doppler Ultrasound (TCD) blood velocity measurements. The study suggests new pressure-dependent experimental paradigms for elucidation of blood flow contributions from extra-cerebral and cerebral tissues. (C) 2013 Optical Society of America (AU)

• FAPESP's process: 12/02500-8 - Instrumentation and methodology development for cerebral oxygenation, blood flow and metabolic monitoring with diffuse optical spectroscopies
• Grantee: Rickson Coelho Mesquita
• Support Opportunities: Research Grants - Young Investigators Grants