| Full text | |
| Author(s): Show less - |
Mesquita, Rickson C.
[1, 2]
;
Schenkel, Steven S.
[1]
;
Minkoff, David L.
[1]
;
Lu, Xiangping
[3]
;
Favilla, Christopher G.
[3]
;
Vora, Patrick M.
[1]
;
Busch, David R.
[1, 4]
;
Chandra, Malavika
[1]
;
Greenberg, Joel H.
[3]
;
Detre, John A.
[3, 5]
;
Yodh, A. G.
[1]
Total Authors: 11
|
| Affiliation: | [1] Univ Penn, Dept Phys & Astron, Philadelphia, PA 19104 - USA
[2] Univ Estadual Campinas, Inst Phys, BR-13083859 Campinas, SP - Brazil
[3] Univ Penn, Dept Neurol, Philadelphia, PA 19104 - USA
[4] Childrens Hosp Philadelphia, Dept Pediat, Div Neurol, Philadelphia, PA 19104 - USA
[5] Univ Penn, Dept Radiol, Philadelphia, PA 19104 - USA
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | BIOMEDICAL OPTICS EXPRESS; v. 4, n. 7, p. 978-994, JUL 1 2013. |
| Web of Science Citations: | 25 |
| Abstract | |
A pilot study explores relative contributions of extra-cerebral (scalp/skull) versus brain (cerebral) tissues to the blood flow index determined by diffuse correlation spectroscopy (DCS). Microvascular DCS flow measurements were made on the head during baseline and breath-holding/hyperventilation tasks, both with and without pressure. Baseline (resting) data enabled estimation of extra-cerebral flow signals and their pressure dependencies. A simple two-component model was used to derive baseline and activated cerebral blood flow (CBF) signals, and the DCS flow indices were also cross-correlated with concurrent Transcranial Doppler Ultrasound (TCD) blood velocity measurements. The study suggests new pressure-dependent experimental paradigms for elucidation of blood flow contributions from extra-cerebral and cerebral tissues. (C) 2013 Optical Society of America (AU) | |
| FAPESP's process: | 12/02500-8 - Instrumentation and methodology development for cerebral oxygenation, blood flow and metabolic monitoring with diffuse optical spectroscopies |
| Grantee: | Rickson Coelho Mesquita |
| Support Opportunities: | Research Grants - Young Investigators Grants |