Advanced search
Start date

Instrumentation and methodology development for cerebral oxygenation, blood flow and metabolic monitoring with diffuse optical spectroscopies


Cerebrovascular disease and neurotrauma are two of the leading causes of death and disability in Brazil and in the world. It has an enormous socioeconomic impact on society, as well as the patient and the patient's family. Although constant microvascular perfusion monitoring is of fundamental importance following cerebral damage, the lack of suitable instrumentation currently limits clinical interventions aiming to optimize cerebral reperfusion. The goal of this project is to build a novel and portable instrument, based on the principles of diffuse optics, that is capable of measuring cerebral perfusion, oxygenation and metabolism in real time, continuously, non-invasively, and at the patient's bedside. Diffuse optics applied to neuroscience is a multidisciplinary and novel research field in Brazil, and the implementation of a pioneering lab such as the one proposed in this project will open up a research area that, in the long term, will improve instrumentation, basic research and clinical applications. Specifically, the implementation of diffuse correlation spectroscopy, a new and innovative technique capable of measuring perfusion continuously and non-invasively, is proposed in this project. We aim to explore the technique's feasibility and high potential for use in the clinic through studies with stroke patients, a disease that affects millions of people and lacks efficient tools to improve patient outcome. In the end, we expect to demonstrate the utility of this promising research to other applications in neurology, such as in patients with traumatic brain injury and carotid stenosis. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
More itemsLess items

Scientific publications (15)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE OLIVEIRA, SUELEN ROSA; MACHADO, ANA CAROLINA C. P.; DE PAULA, JONAS JARDIM; NOVI, SERGIO LUIZ; MESQUITA, RICKSON C.; DE MIRANDA, DEBORA MARQUES; BOUZADA, MARIA CANDIDA F.. Changes of functional response in sensorimotor cortex of preterm and full-term infants during the first year: An fNIRS study. EARLY HUMAN DEVELOPMENT, v. 133, p. 23-28, . (12/02500-8, 13/07559-3)
FAVILLA, CHRISTOPHER G.; MESQUITA, RICKSON C.; MULLEN, MICHAEL; DURDURAN, TURGUT; LU, XIANGPING; KIM, MEERI N.; MINKOFF, DAVID L.; KASNER, SCOTT E.; GREENBERG, JOEL H.; YODH, ARJUN G.; et al. Optical Bedside Monitoring of Cerebral Blood Flow in Acute Ischemic Stroke Patients During Head-of-Bed Manipulation. STROKE, v. 45, n. 5, p. 1269-1274, . (12/02500-8)
BAKER, WESLEY B.; PARTHASARATHY, ASHWIN B.; BUSCH, DAVID R.; MESQUITA, RICKSON C.; GREENBERG, JOEL H.; YODH, A. G.. Modified Beer-Lambert law for blood flow. BIOMEDICAL OPTICS EXPRESS, v. 5, n. 11, p. 4053-4075, . (12/02500-8, 13/07559-3)
NOVI, SERGIO L.; RODRIGUES, RENATO B. M. L.; MESQUITA, RICKSON C.. Resting state connectivity patterns with near-infrared spectroscopy data of the whole head. BIOMEDICAL OPTICS EXPRESS, v. 7, n. 7, p. 2524-2537, . (12/02500-8, 13/07559-3, 15/00576-5)
DE OLIVEIRA, SUELEN ROSA; CABRAL DE PAULA MACHADO, ANA CAROLINA; DE PAULA, JONAS JARDIM; PAIVA DE MORAES, PAULO HENRIQUE; SILVERIO NAHIN, MARIA JULIANA; MAGALHAES, LIVIA DE CASTRO; NOVI, SERGIO L.; MESQUITA, RICKSON C.; DE MIRANDA, DEBORA MARQUES; FERRAREZ BOUZADA, MARIA CANDIDA. Association between hemodynamic activity and motor performance in six-month-old full-term and preterm infants: a functional near-infrared spectroscopy study. NEUROPHOTONICS, v. 5, n. 1, . (12/02500-8, 13/07559-3)
NOVI, SERGIO LUIZ; FORERO, EDWIN JOHAN; IVAN RUBIANES SILVA, JOSE ANGEL; DE SOUZA, NICOLAS GABRIEL S. R.; MARTINS, GIOVANI GRISOTTI; QUIROGA, ANDRES; WU, SHIN-TING; MESQUITA, RICKSON C.. Integration of Spatial Information Increases Reproducibility in Functional Near-Infrared Spectroscopy. FRONTIERS IN NEUROSCIENCE, v. 14, . (13/07559-3, 12/02500-8, 19/21962-1)
FORTI, RODRIGO M.; KATSURAYAMA, MARILISE; MENKO, JULIEN; VALLER, LENISE; QUIROGA, ANDRES; FALCAO, ANTONIO L. E.; LI, LI M.; MESQUITA, RICKSON C.. Real-Time Non-invasive Assessment of Cerebral Hemodynamics With Diffuse Optical Spectroscopies in a Neuro Intensive Care Unit: An Observational Case Study. FRONTIERS IN MEDICINE, v. 7, . (13/07559-3, 12/02500-8, 14/25486-6)
KOGLER, ANGELA S.; BILFINGER, THOMAS V.; GALLER, ROBERT M.; MESQUITA, RICKSON C.; CUTRONE, MICHAEL; SCHENKEL, STEVEN S.; YODH, ARJUN G.; FLOYD, THOMAS F.. Fiber-optic Monitoring of Spinal Cord Hemodynamics in Experimental Aortic Occlusion. ANESTHESIOLOGY, v. 123, n. 6, p. 1362-1373, . (12/02500-8)
MESQUITA, RICKSON C.; FASEYITAN, OLUFUNSHO K.; TURKELTAUB, PETER E.; BUCKLEY, ERIN M.; THOMAS, AMY; KIM, MEERI N.; DURDURAN, TURGUT; GREENBERG, JOEL H.; DETRE, JOHN A.; YODH, ARJUN G.; et al. Blood flow and oxygenation changes due to low-frequency repetitive transcranial magnetic stimulation of the cerebral cortex. Journal of Biomedical Optics, v. 18, n. 6, . (12/02500-8)
MESQUITA, RICKSON C.; D'SOUZA, ANGELA; BILFINGER, THOMAS V.; GALLER, ROBERT M.; EMANUEL, ASHER; SCHENKEL, STEVEN S.; YODH, ARJUN G.; FLOYD, THOMAS F.. Optical Monitoring and Detection of Spinal Cord Ischemia. PLoS One, v. 8, n. 12, . (12/02500-8)
MESQUITA, RICKSON C.; SCHENKEL, STEVEN S.; MINKOFF, DAVID L.; LU, XIANGPING; FAVILLA, CHRISTOPHER G.; VORA, PATRICK M.; BUSCH, DAVID R.; CHANDRA, MALAVIKA; GREENBERG, JOEL H.; DETRE, JOHN A.; et al. Influence of probe pressure on the diffuse correlation spectroscopy blood flow signal: extra-cerebral contributions. BIOMEDICAL OPTICS EXPRESS, v. 4, n. 7, p. 978-994, . (12/02500-8)
MESQUITA, RICKSON C.; PUTT, MARY; CHANDRA, MALAVIKA; YU, GUOQIANG; XING, XIAOMAN; HAN, SUNG WAN; LECH, GWEN; SHANG, YU; DURDURAN, TURGUT; ZHOU, CHAO; et al. Diffuse optical characterization of an exercising patient group with peripheral artery disease. Journal of Biomedical Optics, v. 18, n. 5, . (12/02500-8)
FORTI, RODRIGO MENEZES; KATSURAYAMA, MARILISE; VALLER, LENISE; QUIROGA, ANDRES; SIMIONI, LUIZ; MENKO, JULIEN; FALCAO, ANTONIO L. E.; LI, LI MIN; MESQUITA, RICKSON C.. Real-Time Monitoring of Neurocritical Patients with Diffuse Optical Spectroscopies. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, n. 165, . (13/07559-3, 12/02500-8, 14/25486-6)
GREGORI-PLA, CLARA; MESQUITA, RICKSON C.; FAVILLA, CHRISTOPHER G.; BUSCH, DAVID R.; BLANCO, IGOR; ZIRAK, PEYMAN; FRISK, LISA KOBAYASHI; AVTZI, STELLA; MARUCCIA, FEDERICA; GIACALONE, GIACOMO; et al. Blood flow response to orthostatic challenge identifies signatures of the failure of static cerebral autoregulation in patients with cerebrovascular disease. BMC Neurology, v. 21, n. 1, . (12/02500-8)

Please report errors in scientific publications list by writing to: