Expression of PAR-4 and PHLDA1 is prognostic for overall and disease-free survival in oral squamous cell carcinomas

Autor(es)

Coutinho-Camillo, Claudia Malheiros ^{[1, 2]} ; Lourenco, Silvia Vanessa ^[3] ; Nonogaki, Suely ^[1] ; Vartanian, Jose Guilherme ^[4] ; Nagai, Maria Aparecida ^[5] ; Kowalski, Luiz Paulo ^[4] ; Soares, Fernando Augusto ^{[1, 3]}

Afiliação do(s) autor(es)

^[1] AC Camargo Canc Ctr, Dept Anat Pathol, Sao Paulo - Brazil

^[2] Ctr Int Pesquisa, AC Camargo Canc Ctr, BR-01508010 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Dent, Dept Gen Pathol, Sao Paulo - Brazil

^[4] Hosp AC Camargo Fund Antonio Prudente, Dept Otorhinolaryngol & Head & Neck Surg, Sao Paulo - Brazil

^[5] Univ Sao Paulo, Sch Med, Dept Radiol & Oncol, Discipline Oncol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Virchows Archiv; v. 463, n. 1, p. 31-39, JUL 2013.
• Citações Web of Science: 9

Resumo

PAR-4 is a tumor suppressor protein with a pro-apoptotic function and down-regulation of PAR-4 is seen in a variety of tumors. PHLDA1 gene overexpression has been shown to reduce cell proliferation and induce cell death in a variety of cell types. In this study, 229 cases of oral squamous cell carcinoma (OSCC), arranged in a tissue microarray, were analyzed by immunohistochemistry. PAR-4 expression was predominantly moderate to strong and expression of PHLDA1 was predominantly negative or weak. Cytoplasmic expression of PAR-4 was associated with advanced clinical stage. Expression of PHLDA1 was associated with advanced clinical stage of the tumour. Five-year overall and disease-free survival rates differed significantly between cases that did and cases that did not express PHLDA1, and by multivariate analysis, expression of PHLDA1 and PAR-4 were independent prognostic factors in OSCC patients. Expression of PAR-4 and PHLDA1 is altered in OSCC and might be a valuable prognostic indicator for this disease. (AU)

• Processo FAPESP: 98/14335-2 - Antonio Prudente Cancer Research Center
• Beneficiário: Fernando Augusto Soares
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 07/50608-4 - Identificacao de marcadores moleculares em carcinoma de cabeca e pescoco atraves da tecnica de tissue microarray.
• Beneficiário: Cláudia Malheiros Coutinho Camillo
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 08/57887-9 - Instituto Nacional de Oncogenômica
• Beneficiário: Luiz Paulo Kowalski
• Modalidade de apoio: Auxílio à Pesquisa - Temático