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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Expression of PAR-4 and PHLDA1 is prognostic for overall and disease-free survival in oral squamous cell carcinomas

Texto completo
Autor(es):
Coutinho-Camillo, Claudia Malheiros [1, 2] ; Lourenco, Silvia Vanessa [3] ; Nonogaki, Suely [1] ; Vartanian, Jose Guilherme [4] ; Nagai, Maria Aparecida [5] ; Kowalski, Luiz Paulo [4] ; Soares, Fernando Augusto [1, 3]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] AC Camargo Canc Ctr, Dept Anat Pathol, Sao Paulo - Brazil
[2] Ctr Int Pesquisa, AC Camargo Canc Ctr, BR-01508010 Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Dent, Dept Gen Pathol, Sao Paulo - Brazil
[4] Hosp AC Camargo Fund Antonio Prudente, Dept Otorhinolaryngol & Head & Neck Surg, Sao Paulo - Brazil
[5] Univ Sao Paulo, Sch Med, Dept Radiol & Oncol, Discipline Oncol, Sao Paulo - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: Virchows Archiv; v. 463, n. 1, p. 31-39, JUL 2013.
Citações Web of Science: 9
Resumo

PAR-4 is a tumor suppressor protein with a pro-apoptotic function and down-regulation of PAR-4 is seen in a variety of tumors. PHLDA1 gene overexpression has been shown to reduce cell proliferation and induce cell death in a variety of cell types. In this study, 229 cases of oral squamous cell carcinoma (OSCC), arranged in a tissue microarray, were analyzed by immunohistochemistry. PAR-4 expression was predominantly moderate to strong and expression of PHLDA1 was predominantly negative or weak. Cytoplasmic expression of PAR-4 was associated with advanced clinical stage. Expression of PHLDA1 was associated with advanced clinical stage of the tumour. Five-year overall and disease-free survival rates differed significantly between cases that did and cases that did not express PHLDA1, and by multivariate analysis, expression of PHLDA1 and PAR-4 were independent prognostic factors in OSCC patients. Expression of PAR-4 and PHLDA1 is altered in OSCC and might be a valuable prognostic indicator for this disease. (AU)

Processo FAPESP: 07/50608-4 - Identificação dè marcadores moleculares Èm carcinoma dè cabeça e pescoço através da técnica dè tissue microarray
Beneficiário:Cláudia Malheiros Coutinho Camillo
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 08/57887-9 - Instituto Nacional de Oncogenômica
Beneficiário:Luiz Paulo Kowalski
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 98/14335-2 - Antonio Prudente Cancer Research Center
Beneficiário:Fernando Augusto Soares
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs