Epigenetic Mechanisms in Penile Carcinoma

Autor(es)

Kuasne, Hellen ^{[1, 2]} ; Marchi, Fabio Albuquerque ^[3] ; Rogatto, Silvia Regina ^{[2, 4]} ; de Syllos Colus, Ilce Mara ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Londrina, Dept Gen Biol, BR-86055900 Londrina, PR - Brazil

^[2] AC Camargo Canc Ctr, CIPE, Int Res & Teaching Ctr, BR-01508010 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Inst Math & Stat, Interinst Grad Program Bioinformat, BR-05508090 Sao Paulo - Brazil

^[4] UNESP, Fac Med, Dept Urol, BR-18618970 Botucatu, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 14, n. 6, p. 10791-10808, JUN 2013.
• Citações Web of Science: 11

Resumo

Penile carcinoma (PeCa) represents an important public health problem in poor and developing countries. Despite its unpredictable behavior and aggressive treatment, there have only been a few reports regarding its molecular data, especially epigenetic mechanisms. The functional diversity in different cell types is acquired by chromatin modifications, which are established by epigenetic regulatory mechanisms involving DNA methylation, histone acetylation, and miRNAs. Recent evidence indicates that the dysregulation in these processes can result in the development of several diseases, including cancer. Epigenetic alterations, such as the methylation of CpGs islands, may reveal candidates for the development of specific markers for cancer detection, diagnosis and prognosis. There are a few reports on the epigenetic alterations in PeCa, and most of these studies have only focused on alterations in specific genes in a limited number of cases. This review aims to provide an overview of the current knowledge of the epigenetic alterations in PeCa and the promising results in this field. The identification of epigenetically altered genes in PeCa is an important step in understanding the mechanisms involved in this unexplored disease. (AU)

• Processo FAPESP: 09/52088-3 - O carcinoma de pênis: estudo de um problema brasileiro abordando da morfologia aos mecanismos moleculares
• Beneficiário: José Vassallo
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 10/51601-6 - Perfil de metilação em carcinoma de pênis
• Beneficiário: Silvia Regina Rogatto
• Modalidade de apoio: Auxílio à Pesquisa - Regular