In vitro biomineralization of a novel hydroxyapatite/superhydrophilic multiwalled carbon nanotube nanocomposite using simulated body fluids

Autor(es)

Neves, Marcele Florencio ^[1] ; Brazil, Tayra Rodrigues ^[1] ; Silva Soares, Luis Eduardo ^[2] ; Corat, Evaldo Jose ^[3] ; Marciano, Fernanda Roberta ^[1] ; Lobo, Anderson Oliveira ^[1]

Afiliação do(s) autor(es)

^[1] Univ Vale Paraiba UniVap, Inst Res & Dev IP&D, Lab Biomed Nanotechnol NANOBIO, BR-12244000 Sao Jose Dos Campos, SP - Brazil

^[2] Univ Vale Paraiba UniVap, Inst Res & Dev IP&D, Lab Biomed Vibrat Spect LEVB, BR-12244000 Sao Jose Dos Campos, SP - Brazil

^[3] Natl Inst Space Res INPE, Associated Lab Sensors & Mat LAS, BR-12227010 Sao Jose Dos Campos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS; v. 16, n. 3, p. 650-654, MAY-JUN 2013.
• Citações Web of Science: 0

Resumo

Nanobiomaterials based on superhydrophilic vertically-aligned multi-walled carbon nanotubes (VAMWCNT-O2) are promising for their properties and bone tissue biocompatibility. VAMWCNT-O2 films with nanohydroxyapatite (nHAp) aim to improve mechanical properties and biocompatibility of this new nanocomposite due to its resemblance to bone matrix structure. This study aimed to produce in vitro biomineralized nHAp/VAMWCNT-O2 nanocomposites using simulated body fluid (SBF) with two different pHs (6.10 and 7.40) during 7 days to obtain a new surface design with higher crystalinity and better morphology of nHAp/VAMWCANT-O2 nanocomposites. The objective is to obtain biomineralized nanobiomaterials to enable its applicability as "scaffold" to cellular support and consequent bone tissue formation, accelerating the osseointegration. Layer densification has been achieved due to polycrystalline nanoapatites deposition on surface and between the biomineralized nHAp/VAMWCNT-O2 nanocomposites, without any heat treatment. Therefore, through its characteristics and properties these nanocomposite applications can be considered extremely viable for acceleration of in vivo regenerative processes. (AU)

• Processo FAPESP: 11/20345-7 - Estudo de filmes de carbono-tipo diamante contendo nanopartículas incorporadas para aplicações biomédicas
• Beneficiário: Fernanda Roberta Marciano
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 12/02159-4 - Análise da biomineralização e proliferação celular in vitro de scaffolds de nanohidroxyapatita/nanotubos de carbono verticalmente alinhados
• Beneficiário: Tayra Rodrigues Brazil
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 11/17877-7 - Desenvolvimento de novos scaffolds poliméricos por eletrofiação com incorporação de nanotubos alinhados e nanohidroxiapatita para regeneração óssea
• Beneficiário: Anderson de Oliveira Lobo
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 05/50811-9 - Estudo do colágeno da dentina por técnicas de microanálise
• Beneficiário: Airton Abrahao Martin
• Modalidade de apoio: Auxílio à Pesquisa - Regular