| Texto completo | |
| Autor(es): |
Teles, Helder Lopes
;
Silva, Geraldo Humberto
;
Castro-Gamboa, Ian
;
Bolzani, Vanderlan da Silva
[5]
;
Pereira, José Odair
;
Costa-Neto, Claudio Miguel
;
Haddad, Renato
;
Eberlin, Marcos Nogueira
;
Young, Maria Claudia Marx
;
Araújo, Ângela Regina
Número total de Autores: 10
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Phytochemistry; v. 66, n. 19, p. 2363-2367, Oct. 2005. |
| Área do conhecimento: | Ciências Exatas e da Terra - Química |
| Assunto(s): | Lauraceae Ocotea Fungos Metabólitos Benzopiranos Proliferação celular |
| Resumo | |
An isolate of Curvularia sp. was obtained from the leaves of Ocotea corymbosa, a native plant of the Brazilian Cerrado. The ethyl acetate extract from culture of this fungus afforded two benzopyran derivatives: (2'S)-2-(propan-2'-ol)-5-hydroxy-benzopyran-4-one (2) and 2,3-dihydro-2-methyl-benzopyran-4,5-diol (4); and two known benzopyrans: 2-methyl-5-methoxy-benzopyran-4-one (1) and (2R)-2,3-dihydro-2-methyl-5-methoxy-benzopyran-4-one (3). The structures of 2 and 4 were established on the basis of comprehensive spectroscopic analysis, mainly using 1D and 2D NMR experiments. The benzopyrans 1 and 2 showed weak in vitro antifungal activity against Cladosporium sphaerospermum and C. cladosporioides. Analyses of the biological activities were also carried out on HeLa (human cervix tumor) and CHO (Chinese hamster ovary) cells, aiming to evaluate their potential effects on mammalian cell line proliferation. Results from both cell lines indicated that compound 2 was able to induce cell proliferation: 70% on HeLa cells and 25% on CHO cells. (AU) | |
| Processo FAPESP: | 98/05074-0 - Conservação e uso sustentável da biodiversidade vegetal do Cerrado e da Mata Atlântica: diversidade química e prospecção de medicamentos potenciais |
| Beneficiário: | Vanderlan da Silva Bolzani |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa BIOTA - Temático |