| Full text | |
| Author(s): |
Teles, Helder Lopes
;
Silva, Geraldo Humberto
;
Castro-Gamboa, Ian
;
Bolzani, Vanderlan da Silva
[5]
;
Pereira, José Odair
;
Costa-Neto, Claudio Miguel
;
Haddad, Renato
;
Eberlin, Marcos Nogueira
;
Young, Maria Claudia Marx
;
Araújo, Ângela Regina
Total Authors: 10
|
| Document type: | Journal article |
| Source: | Phytochemistry; v. 66, n. 19, p. 2363-2367, Oct. 2005. |
| Field of knowledge: | Physical Sciences and Mathematics - Chemistry |
| Abstract | |
An isolate of Curvularia sp. was obtained from the leaves of Ocotea corymbosa, a native plant of the Brazilian Cerrado. The ethyl acetate extract from culture of this fungus afforded two benzopyran derivatives: (2'S)-2-(propan-2'-ol)-5-hydroxy-benzopyran-4-one (2) and 2,3-dihydro-2-methyl-benzopyran-4,5-diol (4); and two known benzopyrans: 2-methyl-5-methoxy-benzopyran-4-one (1) and (2R)-2,3-dihydro-2-methyl-5-methoxy-benzopyran-4-one (3). The structures of 2 and 4 were established on the basis of comprehensive spectroscopic analysis, mainly using 1D and 2D NMR experiments. The benzopyrans 1 and 2 showed weak in vitro antifungal activity against Cladosporium sphaerospermum and C. cladosporioides. Analyses of the biological activities were also carried out on HeLa (human cervix tumor) and CHO (Chinese hamster ovary) cells, aiming to evaluate their potential effects on mammalian cell line proliferation. Results from both cell lines indicated that compound 2 was able to induce cell proliferation: 70% on HeLa cells and 25% on CHO cells. (AU) | |
| FAPESP's process: | 98/05074-0 - Conservation and sustainable use of the plant biodiversity from the Cerrado and the Atlantic Forest: chemical diversity and prospecting for potential drugs |
| Grantee: | Vanderlan da Silva Bolzani |
| Support Opportunities: | BIOTA-FAPESP Program - Thematic Grants |