Further bioactive piperidine alkaloids from the flowers and green fruits of Cassia spectabilis

Autor(es)

Viegas Junior, Claudio ; Bolzani, Vanderlan da S. ^[2] ; Furlan, Maysa ; Barreiro, Eliezer J. ; Young, Maria Claudia ; Tomazel, Daniela ; Eberlin, Marcos N.

• Tipo de documento: Artigo Científico
• Fonte: Journal of Natural Products; v. 67, n. 5, p. 908-910, May 2004.
• Área do conhecimento: Ciências Exatas e da Terra - Química
• Assunto(s): Piperidinas Alcaloides Fabaceae Cassia Flores Fruto

Resumo

The flowers of Cassia spectabilis yielded three new piperidine alkaloids, (-)-3-O-acetylspectaline (1), (-)-7-hydroxyspectaline (2), and iso-6-spectaline (3), together with the known (-)-spectaline (4). The green fruits of this plant were also investigated, resulting in the isolation of 1 and 4. Their structures were elucidated using a combination of multidimensional NMR and MS techniques, and relative stereochemistries were established by NOESY correlations and analysis of coupling constants. The DNA-damaging activity of these compounds was evaluated using a mutant yeast, Saccharomyces cerevisiae, assay. (AU)

• Processo FAPESP: 98/05074-0 - Conservação e uso sustentável da biodiversidade vegetal do Cerrado e da Mata Atlântica: diversidade química e prospecção de medicamentos potenciais
• Beneficiário: Vanderlan da Silva Bolzani
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Temático