| Full text | |
| Author(s): |
Viegas Junior, Claudio
;
Bolzani, Vanderlan da S.
[2]
;
Furlan, Maysa
;
Barreiro, Eliezer J.
;
Young, Maria Claudia
;
Tomazel, Daniela
;
Eberlin, Marcos N.
Total Authors: 7
|
| Document type: | Journal article |
| Source: | Journal of Natural Products; v. 67, n. 5, p. 908-910, May 2004. |
| Field of knowledge: | Physical Sciences and Mathematics - Chemistry |
| Abstract | |
The flowers of Cassia spectabilis yielded three new piperidine alkaloids, (-)-3-O-acetylspectaline (1), (-)-7-hydroxyspectaline (2), and iso-6-spectaline (3), together with the known (-)-spectaline (4). The green fruits of this plant were also investigated, resulting in the isolation of 1 and 4. Their structures were elucidated using a combination of multidimensional NMR and MS techniques, and relative stereochemistries were established by NOESY correlations and analysis of coupling constants. The DNA-damaging activity of these compounds was evaluated using a mutant yeast, Saccharomyces cerevisiae, assay. (AU) | |
| FAPESP's process: | 98/05074-0 - Conservation and sustainable use of the plant biodiversity from the Cerrado and the Atlantic Forest: chemical diversity and prospecting for potential drugs |
| Grantee: | Vanderlan da Silva Bolzani |
| Support Opportunities: | BIOTA-FAPESP Program - Thematic Grants |