Multi-enzymatic cascade processes for alkaloids synthesis

• Grant number: 18/07978-0
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2018
• End date: June 30, 2020
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Anita Jocelyne Marsaioli
• Grantee: Anita Jocelyne Marsaioli
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Pyrrolizidine, indolizidine and quinolizidine alkaloids are natural products found in plants, insects and amphibians. Due the vast number of biological activities, these compounds became targets for development of new drugs, and their asymmetric synthesis is a recurrent challenge. Herein, we propose an unprecedented multi-enzymatic cascade reactions involving transaminases, imino reductases, followed by a spontaneous intramolecular Aza-Michael reaction, in order to produce enantiomerically pure pyrrolizidine, indolizidine and quinolizidine alkaloids scaffolds, starting from ±,²-unsaturated keto esters. Another part of this project we aim to study the activity of a new monoamine oxidase (MAO) from the fungus Neopestalotiopsis sp, for further uses of this enzyme to synthetize and resolute piperidine and pyrrolidine alkaloids and other valuable cyclic amines. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DO NASCIMENTO FONTES, JOSE ERALDO; RODRIGUEZ-CATURLA, MAGDEVIS YANET; SANT'ANA, ANDERSON S.; BARROS LOPES, THIAGO INACIO; MARSAIOLI, ANITA JOCELYNE. Foodomics and storage monitoring of three meat cuts by H-1 NMR. CONCEPTS IN MAGNETIC RESONANCE PART A, v. 47A, n. 2, MAR 2018. (14/25028-8, 18/07978-0)

FRAGA, SARA; NASARIO, FABIO DOMINGUES; GONCALVES, DANIEL; CABRAL, FERNANDO ANTONIO; MAXIMO, GUILHERME JOSE; DE ALMEIDA MEIRELLES, ANTONIO JOSE; MARSAIOLI, ANITA JOCELYNE; SAMPAIO, KLICIA ARAUJO. Caferana seeds (Bunchosia glandulifera) as a new source of nutrients: Evaluation of the proximal composition, solvent extraction, bioactive compounds, and delta-lactam isolation. FOOD CHEMISTRY-X, v. 12, DEC 30 2021. (14/50249-8, 18/13207-6, 18/07978-0, 14/21252-0)

MEDICE, ANDRE; LOURENCO, CAROLINA; GASPARIN, REBECA; NAKANO, ADELINO; MARSAIOLI, ANITA J.. Fragrance Retention in Virgin and Bleached Caucasian Hair. JOURNAL OF COSMETIC SCIENCE, v. 69, n. 5, p. 363-370, SEP-OCT 2018. (18/07978-0)

GASPARIN, REBECA M.; THOMAZ, FERNANDA M.; LOURENCO, CAROLINA B.; NAKANO, ADELINO K.; MARSAIOLI, ANITA J.. Influence of Ethnicity and Damage Levels on Fragrance Substantivity on Hair. JOURNAL OF COSMETIC SCIENCE, v. 72, p. 12-pg., 2021-11-01. (18/07978-0)