Fluorescence spectroscopy for the detection of potentially malignant disorders of the oral cavity: analysis of 30 cases

Autor(es)

Francisco, A. L. N. ^[1] ; Correr, W. R. ^[2] ; Azevedo, L. H. ^[3] ; Galletta, V. K. ^[3] ; Pinto, C. A. L. ^[4] ; Kowalski, L. P. ^{[5, 6]} ; Kurachi, C. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Campinas UNICAMP, Sch Dent Piracicaba, Dept Oral Diag, BR-13414018 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Phys Inst Sao Carlos, Dept Phys & Mat Sci, BR-13566590 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Dent Sao Paulo, Special Lab Laser Dent, BR-05508000 Sao Paulo - Brazil

^[4] AC Camargo Hosp, Dept Pathol, BR-01509900 Sao Paulo - Brazil

^[5] AC Camargo Hosp, Dept Head & Neck Surg & Otorhinolaryngol, BR-01509900 Sao Paulo - Brazil

^[6] Natl Sci & Technol Inst Oncogen INCITO, BR-01509900 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Laser Physics; v. 24, n. 1 JAN 2014.
• Citações Web of Science: 0

Resumo

Oral cancer is a major health problem worldwide and although early diagnosis of potentially malignant and malignant diseases is associated with better treatment results, a large number of cancers are initially misdiagnosed, with unfortunate consequences for long-term survival. Fluorescence spectroscopy is a noninvasive modality of diagnostic approach using induced fluorescence emission in tumors that can improve diagnostic accuracy. The objective of this study was to determine the ability to discriminate between normal oral mucosa and potentially malignant disorders by fluorescence spectroscopy. Fluorescence investigation under 408 and 532 nm excitation wavelengths was performed on 60 subjects, 30 with potentially malignant disorders and 30 volunteers with normal mucosa. Data was analyzed to correlate fluorescence patterns with clinical and histopathological diagnostics. Fluorescence spectroscopy used as a point measurement technique resulted in a great variety of spectral information. In a qualitative analysis of the fluorescence spectral characteristics of each type of injury evaluated, it was possible to discriminate between normal and abnormal oral mucosa. The results show the potential use of fluorescence spectroscopy for an improved discrimination of oral disorders. (AU)

• Processo FAPESP: 09/12938-8 - Espectroscopia de Fluorescência para Detecção de Neoplasia Bucal
• Beneficiário: Ana Lucia Noronha Francisco
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 07/57126-5 - Espectroscopia de fluorescência para detecção de neoplasia bucal
• Beneficiário: Luiz Paulo Kowalski
• Modalidade de apoio: Auxílio à Pesquisa - Regular