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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Genetic Variability of Inflammatory Genes in the Brazilian Population

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Autor(es):
dos Santos, Marcelo [1] ; Stur, Elaine [1] ; Maia, Lucas Lima [1] ; Agostini, Lidiane Pignaton [1] ; Peterle, Gabriela Tonini [1] ; Mendes, Suzanny Oliveira [1] ; Tajara, Eloiza Helena [2] ; de Carvalho, Marcos Brasilino [3] ; Louro, Iuri Drumond [4] ; Alvares Silva-Conforti, Adriana Madeira
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Univ Fed Espirito Santo, Programa Posgrad Biotecnol, Vitoria, ES - Brazil
[2] Univ Sao Paulo, Fac Med, Dept Biol Mol, Sao Paulo - Brazil
[3] Hosp Heliopolis, Mol Biol Lab, Sao Paulo - Brazil
[4] Univ Fed Espirito Santo, Dept Ciencias Biol, Nucleo Genet Humana & Mol, Vitoria, ES - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: GENETIC TESTING AND MOLECULAR BIOMARKERS; v. 17, n. 11, p. 844-848, NOV 1 2013.
Citações Web of Science: 4
Resumo

Inflammatory gene variants have been associated with several diseases, including cancer, diabetes, vascular diseases, neurodegenerative diseases, arthritis, and others. Therefore, determining the population genetic composition of inflammation-related genes can be useful for the determination of general risk, prognostic and therapeutic strategies to prevent or cure specific diseases. We have aimed to identify polymorphism genotype frequencies in genes related to the inflammatory response in the Brazilian population, namely, IBL -62AT, IBL -262CT, tumor necrosis factors alpha (TNFa) -238GA, TNFa -308GA, lymphotoxin-alpha (LTa) +80AC, LTa +252AG, FAS -670AG, and FASL -844TC, considering the white, black, and Pardo ethnicities of the SAo Paulo State. Our results suggest that the Brazilian population is under a miscegenation process at the current time, since some genotypes are not in the Hardy-Weinberg equilibrium. In addition, we conclude that the Pardo ethnicity is derived from a complex mixture of ethnicities, including the native Indian population. (AU)

Processo FAPESP: 04/12054-9 - Busca de marcadores de agressividade em tumores de cabeça e pescoço
Beneficiário:Eloiza Helena Tajara da Silva
Linha de fomento: Auxílio à Pesquisa - Temático