Neutrophils LL-37 migrate to the nucleus during overwhelming infection

Autor(es)

da Silva, Fabiano Pinheiro ^[1] ; Rodrigues Medeiros, Maria Cristina ^[2] ; Gomes dos Santos, Angela Batista ^[2] ; Ferreira, Marcelo Alves ^[3] ; Garippo, Ana Lucia ^[4] ; Chammas, Roger ^[5] ; Caldini, Elia ^[3] ; Velasco, Irineu Tadeu ^[1] ; de Souza, Heraldo Possolo ^[1] ; Cesar Machado, Marcel Cerqueira ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Emergency Med, BR-05508 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Dept Pathol, BR-05508 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Dept Cell Biol, BR-05508 Sao Paulo - Brazil

^[4] Univ Sao Paulo, PREMIUM Confocal Microscopy Core Facil, BR-05508 Sao Paulo - Brazil

^[5] Univ Sao Paulo, Dept Oncol, BR-05508 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: TISSUE & CELL; v. 45, n. 5, p. 318-320, OCT 2013.
• Citações Web of Science: 7

Resumo

LL-37 is the only cathelicidin produced by human cells. It is secreted by a variety of cell types, including monocyte/macrophages, neutrophils, mast cells, keratinocytes and epithelial cells, acting on the extracellular milieu by directly killing bacteria or boosting innate immunity. Here, we show that LL-37 translocates to the nucleus following overwhelming infection, putting in evidence that its role may be even broader, with new potential important implications to cell biology. Future studies are necessary to address if LL-37 is able to induce or affect transcription, since it can lead to a novel cell signaling pathway that probably will contribute to the understanding of complex diseases. (C) 2013 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 09/17731-2 - Marcadores de infecção em pacientes críticos
• Beneficiário: Fabiano Pinheiro da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores