Physicochemical aspects behind the size of biodegradable polymeric nanoparticles: A step forward

Autor(es)

de Oliveira, Anderson M. ^[1] ; Jaeger, Eliezer ^[2] ; Jaeger, Alessandro ^[2] ; Stepanek, Petr ^[2] ; Giacomelli, Fernando C. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed ABC, Ctr Ciencias Nat & Humanas, BR-09210170 Santo Andre - Brazil

^[2] Acad Sci Czech Republic, Inst Macromol Chem, CR-16206 Prague 6 - Czech Republic

• Tipo de documento: Artigo Científico
• Fonte: COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS; v. 436, p. 1092-1102, SEP 5 2013.
• Citações Web of Science: 26

Resumo

Surfactant-free PLGA polymeric nanoparticles (PNPs) with hydrodynamic radius (R-H) ranging from 25.8 nm to 128.5 nm were successfully obtained through nanoprecipitation by controlling a variety of physicochemical parameters. The size of the generated PLGA PNPs could be controlled by adjusting the polymer concentration, the choice of organic solvent, mixing different organic solvents or by changing temperature and ionic strength. By optimizing such parameters sub-100 nm uniform PNPs can be produced through this methodology including the advantage and ability to scale-up production. The PNPs have shown a size-dependent effect on the organic solvent and polymer concentration. On the other hand, the polymer-solvent interactions seem not to play a substantial role in the final dimension of the polymer colloids. It has been also evidenced that the size of PNPs can be precisely and linearly tuned by using solvent mixtures as organic phase. (C) 2013 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 12/14087-8 - Desenvolvimento de sistemas poliméricos nanoestruturados com tamanho controlado e sua interação com ambientes biológicos
• Beneficiário: Fernando Carlos Giacomelli
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 12/17841-5 - Produção de nanopartículas poliméricas com tamanho controlado com potencial aplicação na liberação controlada de agentes antitumorais
• Beneficiário: Anderson Marques de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Mestrado