Clinical, cytologic, and histologic features of a mammary micropapillary carcinoma in a dog

Autor(es)

Salgado, Breno S. ^[1] ; Monteiro, Lidianne N. ^[1] ; Colodel, Marcia M. ^[2] ; Figueiroa, Fernanda C. ^[2] ; Soares, Luisa M. ^[2] ; Nonogaki, Suely ^[3] ; Rocha, Rafael M. ^[3] ; Rocha, Noeme S. ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista UNESP, Dept Patol, Fac Med Botucatu, Botucatu, SP - Brazil

^[2] Univ Estadual Paulista UNESP, Dept Clin Vet, Fac Med Vet & Zootecnia, Botucatu, SP - Brazil

^[3] Hosp AC Camargo Fund Antonio Prudente, Fundacao Antonio Prudente, Dept Anat Patol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: VETERINARY CLINICAL PATHOLOGY; v. 42, n. 3, p. 382-385, SEP 2013.
• Citações Web of Science: 1

Resumo

Mammary invasive micropapillary carcinoma is a rare variant of mammary carcinoma that was recently recognized in dogs. The cytologic features and biologic behavior of such neoplasms in dogs have not yet been widely discussed in the veterinary literature. We report the clinical, cytologic, and histologic features of a canine micropapillary carcinoma in a 13-year-old female mongrel dog. The mammary region presented with extreme local pain, severe edema and erythema, and multifocal epidermal ulceration, which is typical for an inflammatory mammary carcinoma. Fine-needle aspirates were highly cellular and consisted of individual cells and papillary cell clusters with characteristics of malignant epithelial cells. Histologic examination revealed neoplastic cells arranged in small papillae without fibrovascular cores, sometimes inside clear lymphatic spaces, indicating lymphovascular invasion. Regional lymph node evaluation revealed metastatic cells. Due to deteriorating clinical condition the dog was euthanatized 5months after mastectomy. At necropsy, metastatic neoplastic mammary cells were found in popliteal and mediastinal lymph nodes, the right femoral biceps muscle, liver, heart, lungs, and urinary bladder. (AU)

• Processo FAPESP: 09/52748-3 - Associacao entre os niveis de residuos piretroides e graus de agressividade dos carcinomas mamarios espontaneos de cadelas
• Beneficiário: Marcia Moleta Colodel
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 10/51596-2 - Análise da imunoexpressão de S100A4 e osteopontina nos carcinomas mamários esporádicos de cadelas
• Beneficiário: Noeme Sousa Rocha
• Modalidade de apoio: Auxílio à Pesquisa - Regular