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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Clinical, cytologic, and histologic features of a mammary micropapillary carcinoma in a dog

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Author(s):
Salgado, Breno S. [1] ; Monteiro, Lidianne N. [1] ; Colodel, Marcia M. [2] ; Figueiroa, Fernanda C. [2] ; Soares, Luisa M. [2] ; Nonogaki, Suely [3] ; Rocha, Rafael M. [3] ; Rocha, Noeme S. [1, 2]
Total Authors: 8
Affiliation:
[1] Univ Estadual Paulista UNESP, Dept Patol, Fac Med Botucatu, Botucatu, SP - Brazil
[2] Univ Estadual Paulista UNESP, Dept Clin Vet, Fac Med Vet & Zootecnia, Botucatu, SP - Brazil
[3] Hosp AC Camargo Fund Antonio Prudente, Fundacao Antonio Prudente, Dept Anat Patol, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: VETERINARY CLINICAL PATHOLOGY; v. 42, n. 3, p. 382-385, SEP 2013.
Web of Science Citations: 1
Abstract

Mammary invasive micropapillary carcinoma is a rare variant of mammary carcinoma that was recently recognized in dogs. The cytologic features and biologic behavior of such neoplasms in dogs have not yet been widely discussed in the veterinary literature. We report the clinical, cytologic, and histologic features of a canine micropapillary carcinoma in a 13-year-old female mongrel dog. The mammary region presented with extreme local pain, severe edema and erythema, and multifocal epidermal ulceration, which is typical for an inflammatory mammary carcinoma. Fine-needle aspirates were highly cellular and consisted of individual cells and papillary cell clusters with characteristics of malignant epithelial cells. Histologic examination revealed neoplastic cells arranged in small papillae without fibrovascular cores, sometimes inside clear lymphatic spaces, indicating lymphovascular invasion. Regional lymph node evaluation revealed metastatic cells. Due to deteriorating clinical condition the dog was euthanatized 5months after mastectomy. At necropsy, metastatic neoplastic mammary cells were found in popliteal and mediastinal lymph nodes, the right femoral biceps muscle, liver, heart, lungs, and urinary bladder. (AU)

FAPESP's process: 10/51596-2 - S100A4 and osteopontin immunoexpression evaluation in canine spontaneous mammary carcinomas
Grantee:Noeme Sousa Rocha
Support Opportunities: Regular Research Grants